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Male reproductive health and intergenerational metabolic responses from a small RNA perspective
Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-9182-9401
Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
2020 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 288, no 3, p. 305-320Article, review/survey (Refereed) Published
Abstract [en]

The world has recently experienced a decline in male reproductive (e.g. sperm counts and motility) and metabolic (e.g. obesity and diabetes) health. Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors for such paternal intergenerational metabolic responses (IGMRs) involve small noncoding RNAs (sncRNAs) that often increase in spermatozoa during the last days of maturation in the epididymis. We and others have shown that the metabolic state - depending on factors such as diet, obesity and physical exercise - may affect sperm quality and sperm sncRNA. Together, this suggests that there are overlapping aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses. In this review, we present a theoretical framework for an overlap of these aetiologies by exploring the advances in our understanding of the roles of sncRNA in spermatogenesis and offspring development. A special focus will lie on novel findings about tRNA-derived small RNA (tsRNA), rRNA-derived small RNA (rsRNA) and small mitochondrial RNA (mitoRNA), and their emerging roles in intergenerational metabolic and reproductive health.

Place, publisher, year, edition, pages
WILEY , 2020. Vol. 288, no 3, p. 305-320
Keywords [en]
small RNA; metabolic syndrome; obesity; cell biology; diet; reproduction; sperm; infertility; epigenetic inheritance; sperm motility
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
URN: urn:nbn:se:liu:diva-169980DOI: 10.1111/joim.13096ISI: 000559988500005PubMedID: 32415866OAI: oai:DiVA.org:liu-169980DiVA, id: diva2:1471034
Note

Funding Agencies|Knut och Alice Wallenbergs StiftelseKnut & Alice Wallenberg Foundation [2015.0165]; Ragnar Soderbergs stiftelse; Vetenskapsradet [2015-03141]

Available from: 2020-09-28 Created: 2020-09-28 Last updated: 2021-05-04

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CiteExportLink to record
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