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Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil
Fiocruz MS, Brazil.
Fiocruz MS, Brazil.
Fiocruz MS, Brazil.
Fiocruz MS, Brazil.
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2020 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 82, article id 104280Article in journal (Refereed) Published
Abstract [en]

Norovirus has emerged as an important viral agent of acute pediatric gastroenteritis, with a growing genetic diversity reported in the last decades. Histo-blood group antigens (HBGAs) present on the surface of enterocytes are susceptibility factors for norovirus infection and differ between populations which could affects the epidemiology and evolution of these viruses. This study investigated the frequency, incidence and genetic diversity of noroviruses in a cohort of rotavirus A vaccinated children in association to the host HBGA (Secretor/Lewis) genetic susceptibility profile. Norovirus genogroups I and II (GI/GII) were screened by RT-qPCR in 569 stool samples from 132 children followed-up from birth to 11 months of age during 2014-2018. Noroviruses were identified in 21.2% of children enrolled in this study, with a norovirus detection rate of 5.6% (32/569), in 17.1% and 4.7% of acute diarrheic episodes (ADE) and non-ADE, respectively. The norovirus incidence was 5.8 infections per 100 child-months. Partial nucleotide sequencing characterized six different norovirus genotypes, with GII.4 Sydney 2012 being detected in 50% associated with three different polymerase genotypes (GII.31, GII.P16 and GII.P4 New Orleans 2009). FUT3 genotyping was yielded seven new mutations in this population. A significant association between symptomatic norovirus infection and secretor profile could be inferred.

Place, publisher, year, edition, pages
ELSEVIER , 2020. Vol. 82, article id 104280
Keywords [en]
Norovirus; GII.4 Sydney; Susceptibility; Secretor; Lewis; Birth community-cohort
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-170692DOI: 10.1016/j.meegid.2020.104280ISI: 000571457700006PubMedID: 32165242OAI: oai:DiVA.org:liu-170692DiVA, id: diva2:1477674
Note

Funding Agencies|Oswaldo Cruz Institute/Fiocruz/PAEF2; Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro" (FAPERJ)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ); "National Council for Scientific and Technological Development" (CNPq)National Council for Scientific and Technological Development (CNPq) [424,376/2016-4]

Available from: 2020-10-19 Created: 2020-10-19 Last updated: 2021-12-28

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Nordgren, JohanSvensson, Lennart
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Citation style
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