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A risk score model to predict incidental gallbladder cancer in patients scheduled for cholecystectomy
Lund Univ, Sweden; Skane Univ Hosp, Sweden.
Skane Univ Hosp, Sweden; Lund Univ, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
Lund Univ, Sweden; Skane Univ Hosp, Sweden.
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2020 (English)In: American Journal of Surgery, ISSN 0002-9610, E-ISSN 1879-1883, Vol. 220, no 3, p. 741-744Article in journal (Refereed) Published
Abstract [en]

Background: Gallbladder cancer (GBC) has a poor prognosis. The aim was to develop and validate a preoperative risk score for incidental gallbladder cancer (IGBC) in patients scheduled for cholecystectomy. Methods: Data registered in the nationwide Swedish Registry for Gallstone Surgery (GallRiks) was analyzed, including the derivation cohort (n = 28915, 2007-2014) and the validation cohort (n = 7851, 2014-2016). An additive risk score model based on odds ratio was created. Results: The scoring model to predict IGBC includes age, female gender, previous cholecystitis, and either jaundice or acute cholecystitis. The calibration by HL test and discrimination by AUROC was 8.27 (P = 0.291) and 0.76 in the derivation cohort (214 IGBC) and 14.28 (P = 0.027) and 0.79 in the validation cohort (35 IGBC). The scoring system was applied to three risk-groups, based on the risk of having IGBC, eg. the high-risk group (>8 points) included 7878 patients, with 154 observed and 148 expected IGBC cases. Conclusion: We present the first risk score model to predict IGBC. The model estimates the expected risk for the individual patient and may help to optimize treatment strategies. (c) 2020 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC , 2020. Vol. 220, no 3, p. 741-744
Keywords [en]
Incidental gallbladder cancer; Risk score model
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-170671DOI: 10.1016/j.amjsurg.2020.01.039ISI: 000570213500047PubMedID: 32037044OAI: oai:DiVA.org:liu-170671DiVA, id: diva2:1477693
Note

Funding Agencies|Erik and Angelica Sparres research foundation; Government grant for clinical research

Available from: 2020-10-19 Created: 2020-10-19 Last updated: 2020-10-19

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Lundgren, LindaSandström, Per
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Surgery in Linköping
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