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Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association
Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.ORCID iD: 0000-0002-1904-5554
Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
2010 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Neuroscience, Vol. 168, no 3, p. 706-714Article in journal (Refereed) Published
Abstract [en]

Reward-mediated associative learning is important for recognizing the significance of environmental cues. Such learning involves convergence of multimodal sensory inputs with circuits involved in affective and memory processes. Dopamine-dependent plasticity in the striatum plays a pivotal role, but the wider circuits engaged in cue-reward association are poorly understood. To identify candidate structures that may be of particular interest for further detailed electrophysiological and functional analysis, we quantified c-Fos expression in a selection of brain structures. c-Fos is a well-known marker of cell activation with additional potential importance for synaptic plasticity. We compared c-Fos expression between animals exposed to 100 pairings of a novel conditioned stimulus with a subsequent reward, and control animals exposed to the same number of cues and rewards, but where the cues and rewards occurred at random with respect to each other. We found significant increases in c-Fos expression in the superior colliculus in the group exposed to cue-reward pairing. This is consistent with previous recordings in conscious animals, showing modulation of phasic visual responses of single collicular neurons depending on their association with reward. Further, the data also suggest the possibility that the thalamic paraventricular nucleus and septal nuclei may be selectively activated during cue-reward association learning. Little is known of the neurophysiological responses in these structures during such tasks, so the present results suggest they would be targets of interest for future single-neuron recording experiments, designed to confirm whether the neurons show learning-specific modulation.

Place, publisher, year, edition, pages
Elsevier, 2010. Vol. 168, no 3, p. 706-714
Keywords [en]
classical conditioning, immediate early gene, Fos, associative learning, Pavlovian conditioning, rat
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-171572DOI: 10.1016/j.neuroscience.2010.04.018ISI: 000278611500012PubMedID: 20399252Scopus ID: 2-s2.0-77953120402OAI: oai:DiVA.org:liu-171572DiVA, id: diva2:1503239
Available from: 2020-11-23 Created: 2020-11-23 Last updated: 2020-12-01Bibliographically approved

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Igelström, Kajsa

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