liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Synthesis of Sheet Like Nanostructures of NiO Using Potassium Dichromate as Surface Modifying Agent for the Sensitive and Selective Determination of Amlodipine Besylate (ADB) Drug
Tsinghua Univ Beijing, Peoples R China; Univ Sindh Jamshoro, Pakistan.
Univ Karachi, Pakistan.
Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
Univ Karachi, Pakistan.
Show others and affiliations
2021 (English)In: Electroanalysis, ISSN 1040-0397, E-ISSN 1521-4109, Vol. 33, no 5, p. 1121-1128Article in journal (Refereed) Published
Abstract [en]

The monitoring of hypertension drugs is very critical and important to sustain a healthy life. In this study, we have synthesized nickel oxide (NiO) nanostructures using potassium dichromate as surface modifying agent by hydrothermal method. These NiO nanostructures were found highly active for the oxidation of ADB besylate (ADB). The unit cell structure and morphology were investigated by scanning electron microscopy (SEM) and powder X-ray diffraction (XRD) techniques. The SEM study has confirmed the nano sheet like morphology and XRD analysis has described the cubic unit arrays of NiO. After the physical characterization, NiO nanostructures were used to modify the surface of glassy carbon electrode (GCE) by drop casting method. Then cyclic voltammetry (CV) was used to characterize the electrochemical activity of NiO nanostructures in the0.1 M phosphate buffer solution of pH 10.0 and a well resolved oxidation peak was identified at 0.70 V. The linear range for the NiO nanostructures was observed from 20-90 nM with a regression coefficient of 0.99 using CV. The calculated limit of detection (LOD) was 2.125 nM and the limit of quantification (LOQ) was 4.08 nM. Further to validate the CV calibration plot, an amperometry experiment was performed on the NiO nanostructures and sensors exhibited a linear range of 10 nM to 115 nM with LOD of 1.15 nM. The proposed approach was successfully used for the determination of ADB from commercial tablets and it reveals that the sensor could be capitalized to monitor ADB concentrations from pharmaceutical products. The use of potassium dichromate as a surface modifying agent for the metal oxide nanostructures may be of great interest to manipulate their crystal and surface properties for the extended range of biomedical and energy related applications.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2021. Vol. 33, no 5, p. 1121-1128
Keywords [en]
ADB besylate(ADB); Nickel oxide nanostructures; Cyclic Voltammetry (CV); Amperometry; Phosphate buffer solution
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-173471DOI: 10.1002/elan.202060571ISI: 000611073900001OAI: oai:DiVA.org:liu-173471DiVA, id: diva2:1530034
Note

Funding Agencies|Department of Metallurgy and Materials Engineering, Mehran University of Engineering and Technology (MUET), Jamshoro, Sindh; King Saud University, Riyadh, Saudi ArabiaKing Saud University [RSP-2021/79]

Available from: 2021-02-20 Created: 2021-02-20 Last updated: 2022-03-17

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Search in DiVA

By author/editor
Tahira, Aneela
By organisation
Physics, Electronics and MathematicsFaculty of Science & Engineering
In the same journal
Electroanalysis
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 123 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf