Temporary effects of neonatal overfeeding on homeostatic control of food intake involve alterations in POMC promoter methylation in male ratsShow others and affiliations
2021 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 522, article id 111123Article in journal (Refereed) Published
Abstract [en]
A small litter (SL) model was used to determine how neonatal overfeeding affects the homeostatic control of food intake in male rats at weaning and postnatal day (PND) 90. At PND4, litters were reduced to small (4 pups/dam) or normal (10 pups/dam) litters. At weaning, SL rats showed higher body weight and characteristic features of the metabolic syndrome. Gene expression of pro-opiomelanocortin (POMC), cocaine and amphetamine regulated transcript, neuropeptide Y (NPY) and leptin and ghrelin (GHSR) receptors were increased and POMC promoter was hypomethylated in arcuate nucleus, indicating that the early development of obesity may involve the GHSR/NPY system and changes in POMC methylation state. At PND90, body weight, metabolic parameters and gene expression were restored; however, POMC methylation state remained altered. This work provides insight into the effects of neonatal overfeeding, showing the importance of developmental plasticity in restoring early changes in central pathways involved in metabolic programming.
Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2021. Vol. 522, article id 111123
Keywords [en]
Small litter; Postnatal programing; Overweight; Homeostatic system; DNA methylation
National Category
Medical Genetics and Genomics
Identifiers
URN: urn:nbn:se:liu:diva-174126DOI: 10.1016/j.mce.2020.111123ISI: 000614234900006PubMedID: 33338550OAI: oai:DiVA.org:liu-174126DiVA, id: diva2:1537451
Note
Funding Agencies|National Scientific and Technical Research Council (CONICET)Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP 11220150100338CO 2016-2019]; National University of Littoral [0420150100085LI]
2021-03-152021-03-152025-02-10