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Circulating Dendritic Cells from Celiac Disease Patients Display a Gut-Homing Profile and are Differentially Modulated by Different Gliadin-Derived Peptides
Mucosal Immunology Laboratory, Instituto de Biología y Genética Molecular (IBGM), University of Valladolid-CSIC, Spain.ORCID iD: 0000-0001-8906-3101
Flow Cytometry facility, Instituto de Biología y Genética Molecular (IBGM), University of Valladolid-CSIC, Spain.
Mucosal Immunology Laboratory, Instituto de Biología y Genética Molecular (IBGM), University of Valladolid-CSIC, Spain.
Digestive Disease Unit, Hospital Clínico Universitario de Valladolid, Spain.
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2020 (English)In: Molecular Nutrition & Food Research, ISSN 1613-4125, E-ISSN 1613-4133, Vol. 64, no 6, article id e1900989Article in journal (Refereed) Published
Abstract [en]

Circulating dendritic cell (DC) and monocyte subsets contribute to the pool of intestinal DC and macrophages in celiac disease (CeD), an autoimmune gut disorder triggered by dietary gluten. Here, this study aims to characterize these circulating subsets in CeD and assess the effect of different gliadin-derived peptides on conventional DC (cDC).

Place, publisher, year, edition, pages
Wiley-VCH , 2020. Vol. 64, no 6, article id e1900989
Keywords [en]
T cells; antigen presentation; autoimmune diseases; gliadin; monocytes
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-174256DOI: 10.1002/mnfr.201900989PubMedID: 31970917OAI: oai:DiVA.org:liu-174256DiVA, id: diva2:1538024
Note

Funding agencies: Asociación de Celiacos y Sensibles al Gluten de Madrid (Spain), the Spanish Ministry of Science (RYC‐2017‐21606), and the Spanish Ministry of Economics and Competitiveness (RTC‐2014‐2401).

Available from: 2021-03-17 Created: 2021-03-17 Last updated: 2021-05-06Bibliographically approved

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Escudero-Hernández, Celia

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