Survival and prognostic factors after transplantation, resection and ablation in a national cohort of early hepatocellular carcinomaShow others and affiliations
2021 (English)In: HPB, ISSN 1365-182X, E-ISSN 1477-2574, Vol. 23, no 3, p. 394-403Article in journal (Refereed) Published
Abstract [en]
BackgroundIn patients with early hepatocellular cancer (HCC) and preserved liver function, the choice between transplantation, resection and ablation and which factors to consider is not obvious and guidelines differ. In this national cohort study, we aimed to compare posttreatment survival in patients fulfilling predefined criteria, and to analyse preoperative risk factors that could influence decision.MethodsWe used data from HCC-patients registered with primary transplantation, resection or ablation 2008–2016 in the SweLiv-registry. In Child A-subgroups, 18–75 years, we compared survival after transplantation or resection, with different tumour criteria; either corresponding to our transplantation criteria (N = 257) or stricter with single tumours ≤50 mm (N = 159). A subgroup with single tumours ≤30 mm, compared all three treatments (N = 193).ResultsWe included 1022 HCC-patients; transplantation n = 223, resection n = 438, ablation n = 361. In the transplant criteria subgroup, differences in five-year survival, adjusted for age and gender, were not significant, with 71.2% (CI 62.3–81.3) after transplantation (n = 109) and 63.5% (CI 54.9–73.5) after resection (n = 148). Good liver function (Child 5 vs. 6, Albumin ≥36), increased the risk after transplantation, but decreased the risk after resection and ablation.ConclusionEven within Child A, detailed liver function assessment is important before treatment decision, and for stratifying survival comparisons.
Place, publisher, year, edition, pages
Elsevier , 2021. Vol. 23, no 3, p. 394-403
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-174343DOI: 10.1016/j.hpb.2020.07.010ISI: 000632022800007PubMedID: 32792306OAI: oai:DiVA.org:liu-174343DiVA, id: diva2:1538653
2021-03-202021-03-202022-04-05Bibliographically approved