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Epithelial cell dysfunction in coeliac disease
Linköping University, Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-8906-3101
2021 (English)In: Immunopathology of celiac disease / [ed] Ainara Castellanos-Rubio, Lorenzo Galluzzi, Elsevier , 2021, Vol. 358, p. 133-164Chapter in book (Refereed)
Abstract [en]

The intestinal epithelium limits host-luminal interactions and maintains gut homeostasis. Breakdown of the epithelial barrier and villous atrophy are hallmarks of coeliac disease. Besides the well characterized immune-mediated epithelial damage induced in coeliac mucosa, constitutional changes and early gluten direct effects disturb intestinal epithelial cells. The subsequent modifications in key epithelial signaling pathways leads to outnumbered immature epithelial cells that, in turn, facilitate epithelial dysfunction, promote crypt hyperplasia, and increase intestinal permeability. Consequently, underlying immune cells have a greater access to gluten, which boosts the proinflammatory immune response against gluten and positively feedback the epithelial damage loop. Gluten-free diet is an indispensable treatment for coeliac disease patients, but additional therapies are under development, including those that reinforce intestinal epithelial healing. In this chapter, we provide an overview of intestinal epithelial cell disturbances that develop during gluten intake in coeliac disease mucosa.

Place, publisher, year, edition, pages
Elsevier , 2021. Vol. 358, p. 133-164
Series
International Review of Cell and Molecular Biology, ISSN 1937-6448
Keywords [en]
Epigenetics; Gluten-free diet; Gut barrier; Intestinal epithelial cell; Intestinal permeability; Intestinal stem cell; Methylation; Microbiota; Organoid; Wnt signaling
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-174425DOI: 10.1016/bs.ircmb.2020.09.007ISI: 000750008200005PubMedID: 33707053Libris ID: n27jtx22lv5tr7bvISBN: 9780323853118 (electronic)OAI: oai:DiVA.org:liu-174425DiVA, id: diva2:1538684
Available from: 2021-03-21 Created: 2021-03-21 Last updated: 2024-11-28Bibliographically approved

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Publisher's full textPubMedhttps://libris.kb.se/bib/n27jtx22lv5tr7bv

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Escudero-Hernández, Celia

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CiteExportLink to record
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