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Improved coronary calcification quantification using photon-counting-detector CT: an ex vivo study in cadaveric specimens
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Mayo Clin, MN USA.
Mayo Clin, MN USA.
Mayo Clin, MN USA.
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2021 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 31, no 9, p. 6621-6630Article in journal (Refereed) Published
Abstract [en]

Objectives To compare the accuracy of coronary calcium quantification of cadaveric specimens imaged from a photon-counting detector (PCD)-CT and an energy-integrating detector (EID)-CT. Methods Excised coronary specimens were scanned on a PCD-CT scanner, using both the PCD and EID subsystems. The scanning and reconstruction parameters for EID-CT and PCD-CT were matched: 120 kV, 9.3-9.4 mGy CTDIvol, and a quantitative kernel (D50). PCD-CT images were also reconstructed using a sharper kernel (D60). Scanning the same specimens using micro-CT served as a reference standard for calcified volumes. Calcifications were segmented with a half-maximum thresholding technique. Segmented calcified volume differences were analyzed using the Friedman test and post hoc pairwise Wilcoxon signed rank test with the Bonferroni correction. Image noise measurements were compared between EID-CT and PCD-CT with a repeated-measures ANOVA test and post hoc pairwise comparison with the Bonferroni correction. A p < 0.05 was considered statistically significant. Results The volume measurements in 12/13 calcifications followed a similar trend: EID-D50 > PCD-D50 > PCD-D60 > micro-CT. The median calcified volumes in EID-D50, PCD-D50, PCD-D60, and micro-CT were 22.1 (IQR 10.2-64.8), 21.0 (IQR 9.0-56.5), 18.2 (IQR 8.3-49.3), and 14.6 (IQR 5.1-42.4) mm(3), respectively (p < 0.05 for all pairwise comparisons). The average image noise in EID-D50, PCD-D50, and PCD-D60 was 60.4 (+/- 3.5), 56.0 (+/- 4.2), and 113.6 (+/- 8.5) HU, respectively (p < 0.01 for all pairwise comparisons). Conclusion The PCT-CT system quantified coronary calcifications more accurately than EID-CT, and a sharp PCD-CT kernel further improved the accuracy. The PCD-CT images exhibited lower noise than the EID-CT images.

Place, publisher, year, edition, pages
SPRINGER , 2021. Vol. 31, no 9, p. 6621-6630
Keywords [en]
X-ray tomography; Coronary artery disease; Cadaver; Artifacts
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-174882DOI: 10.1007/s00330-021-07780-6ISI: 000628482400006PubMedID: 33713174Scopus ID: 2-s2.0-85102697280OAI: oai:DiVA.org:liu-174882DiVA, id: diva2:1542587
Note

Funding Agencies|National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 EB016966, C06 RR018898]; Mayo Clinic X-ray Imaging Research Core; Mayo Clinic-Karolinska Institutet Collaboration platform; ALF grants, Region Ostergotland

Available from: 2021-04-08 Created: 2021-04-08 Last updated: 2022-03-21Bibliographically approved

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Sandstedt, MårtenPersson, Anders
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Division of Diagnostics and Specialist MedicineFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
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