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Development of water-soluble curcumin grafted magnetic nanoparticles for enhancing bioavailability, fluorescence, and magnetic resonance imaging activity
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering. Saveetha Inst Med & Tech Sci, India.
CSIR Cent Leather Res Inst CLRI, India.
2021 (English)In: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 294, article id 129763Article in journal (Refereed) Published
Abstract [en]

The chemo-fluorescent drug curcumin (CUR) is a safe and effective anticancer agent. The primary limitation of CUR is its poor solubility in water, which limits its bioavailability. We have developed an efficient chemotherapeutic and amorphous magneto-fluorescent CUR grafted magnetic nanoparticles (CUR-MAG NPs) using wet chemical process. The CUR grafting of MAG NPs improved the solubility, bioavailability, and internalization activities of CUR. CUR-MAG NPs can be used as a novel platform for in vivo biomedical applications. (c) 2021 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER , 2021. Vol. 294, article id 129763
Keywords [en]
Curcumin; Magnetic nanoparticles; Cellular internalization; Magnetic Resonance Imaging
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URN: urn:nbn:se:liu:diva-176138DOI: 10.1016/j.matlet.2021.129763ISI: 000651916500028OAI: oai:DiVA.org:liu-176138DiVA, id: diva2:1562059
Note

Funding Agencies|DST-SERBDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [PDF/2016/000423]; SERBDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India; Department of Health Research for Young Scientist Fellowship [12014/33/2020HR]

Available from: 2021-06-08 Created: 2021-06-08 Last updated: 2021-06-08

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