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Prevalence of symptoms in relation to androgen concentrations in women using estrogen plus progestogen and women using estrogen alone
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences.
Lund University.
Lund University.
2009 (English)In: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, ISSN 1072-3714, Vol. 16, no 1, 149-155 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Women using estrogen plus progestogen therapy sometimes report difficult to describe symptoms, eg, changes in libido, mood, and memory, that may be related to decreased androgens. To evaluate the prevalence or such symptoms and relate these symptoms to androgen levels ill women using estrogen plus progestogen therapy, data from the Womens Health in the Lund Area Study were analyzed.

Design: A total of 2,816 women using estrogen plus progestogen therapy were asked to complete a questionnaire consisting of questions concerning sexual well-being and different aspects of quality of life. Serum concentrations of testosterone, androstendione, sex lion-none-binding globulin, and estradiol were measured.

Results: A total of 2,048 questionnaires were eligible for evaluation. Almost 40% of the women reported decreased libido. Approximately 70% were satisfied with their current sex life. Eight percent reported that intercourse was unpleasant because of vaginal dryness. No evident associations were found between libido and serum hormone concentrations. The most positive effects of estrogen plus progestogen therapy concerning memory and urinary tract and vaginal complaints were found in women with the highest and/or moderate testosterone levels (P < 0.05).

Conclusions: We found no strong association between symptoms related to sexual well-being or quality of life and androgen concentrations in this study. Estrogen plus progestogen therapy did not seem to affect

Place, publisher, year, edition, pages
2009. Vol. 16, no 1, 149-155 p.
Keyword [en]
Menopause, Testosterone, Androgens, Hormone therapy, Estrogen therapy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16509DOI: 10.1097/gme.0b013e31817f45b6OAI: oai:DiVA.org:liu-16509DiVA: diva2:158116
Available from: 2009-01-30 Created: 2009-01-30 Last updated: 2014-09-16

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Spetz, Anna-Clara

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Obstetrics and gynecologyFaculty of Health SciencesDepartment of Gynaecology and Obstetrics in LinköpingOccupational and Environmental Medicine
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