liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma
Sichuan University.
Sichuan University.
Sichuan University.
Sichuan University.
Show others and affiliations
2009 (English)In: EUROPEAN JOURNAL OF CANCER PREVENTION, ISSN 0959-8278, Vol. 18, no 1, 40-45 p.Article in journal (Refereed) Published
Abstract [en]

As proliferation is essential for Progression from normal cells to tumor, certain markers specific to proliferating cells may permit detection of premalignant lesions. Here, we aimed to evaluate the possible value of a proliferation marker, minichromosome maintenance 2 (MCM2), in the early diagnosis of colorectal cancer, by analyzing the difference in MCM2 expression among normal mucosa, adenoma, and adenocarcinoma, and investigating the relationship of MCM2 expression in adenomas with clinicopathologic variables. Using immunohistochemistry and real-time reverse transcription-PCR, we observed that the expression of MCM2 protein was present on basal third to half of colonic crypts in normal mucosa, whereas throughout the epithelium in adenomas and adenocarcinomas, the expression of MCM2 mRNA in adenocarcinomas was significantly higher than in adenomas (P=0.001), whereas the difference between adenoma and normal mucosa was not significant (P=0.184); we also found that the expression of MCM2 mRNA tended to be increased in the adenomas with high-grade dysplasia, or in older patients, respectively, compared with those with low-grade dysplasia, and younger patients. These results suggested the potential value of MCM2 in early diagnosis of colorectal cancer.

Place, publisher, year, edition, pages
2009. Vol. 18, no 1, 40-45 p.
Keyword [en]
colonic adenocarcinoma adenoma, minichromosome maintenance protein 2, real-time reverse transcription-PCR
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16519DOI: 10.1097/CEJ.0b013e32830c8d5aOAI: oai:DiVA.org:liu-16519DiVA: diva2:158126
Note
This is a non-final version of an article published in final form in: Yong Wang, Yuan Li, Wen-Yan Zhang, Qing-Jie Xia, Hong-Guang Li, Rong Wang, Lie Yang, Xiao-Feng Sun and Zong-Guang Zhou, mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma, 2009, EUROPEAN JOURNAL OF CANCER PREVENTION, (18), 1, 40-45. http://dx.doi.org/10.1097/CEJ.0b013e32830c8d5a Copyright: Lippincott Williams & Wilkins; 1999 http://www.lww.com/ Available from: 2009-02-02 Created: 2009-01-30 Last updated: 2009-08-21Bibliographically approved

Open Access in DiVA

fulltext(548 kB)401 downloads
File information
File name FULLTEXT01.pdfFile size 548 kBChecksum SHA-512
9c1dda1d1fca34d49fb6315d795b5a38acfaa69b6f9bc598768c9838ab1c2d5c5e28b88e02be287c6fc2c4c08de31d3cf89bd2de76128625c0e885137f83c423
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Sun, Xiao-Feng

Search in DiVA

By author/editor
Sun, Xiao-Feng
By organisation
Oncology Faculty of Health SciencesDepartment of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 401 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 123 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf