Physical activity, blood glucose and c-peptide in healthy school-children
2010 (English)Article in journal (Refereed) Submitted
Background: The incidence of type 1 diabetes is increasing. This increase must be due to environmental factors. Low physical activity and overweight/obesity among children may play a role.
Objective: The aim of the current study was to investigate how lack of physical activity relates to blood glucose value and insulin sensitivity in healthy children. A second aim was to explore whether low physical activity is related to overweight/obesity in children.
Methods: This study is part of the prospective cohort study ‘All Babies In southeast Sweden’ (ABIS). 199 children from different schools participated. Pedometersteps during 4 days were registered as well as height and weight, and fasting blood glucose and serum C-peptide were determined. Parents answered a questionnaire.
Results: Fewer dailysteps correlated to higher BMI (P= 0.019) and waist circumference (P=0.018) as well as to higher C-peptide (P= 0.044), HOMA IR (P=0.046) and HOMA β-cell (P=0.022). Children who spent more hours/day in front of TV/Video had higher waist circumference (P= 0.033) and higher fasting blood glucose values (P=0.016).
Conclusion: Already in early school-age low physical activity is related to increased BMI and waist circumference. These signs and low physical activity are accompanied by a decreased insulin sensitivity compensated for by significantly increased insulin secretion. Low physical activity may cause beta cell stress which might contribute to an autoimmune process in individuals predisposed to autoimmunity, and thereby to the increasing incidence of Type 1 diabetes in children.
Place, publisher, year, edition, pages
Blood glucose, Children, Obesity, Physical activity
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16606OAI: oai:DiVA.org:liu-16606DiVA: diva2:159022