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Serum zinc in small children with coeliac disease
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Norrköping.
Norrtälje Hospital.
Astrid Lindgren's Children Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology . Linköping University, Faculty of Health Sciences.
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2009 (English)In: ACTA PAEDIATRICA, ISSN 0803-5253, Vol. 98, no 2, 343-345 p.Article in journal (Refereed) Published
Abstract [en]

In coeliac disease (CD) there is a gluten-induced small bowel enteropathy leading to malabsorption of various nutrients, vitamins and trace elements. Low levels of serum zinc have been reported in adults with untreated CD. In the present study we related the serum concentration of zinc to the morphology of the small bowel mucosa in 58 children, all under 4 years of age and under investigation for coeliac disease. The mean serum concentration of zinc (mean +/- SD; mu mol/L) was significantly lower in children with untreated CD (9.7 +/- 2.0) (n = 11) compared to non-coeliac children without enteropathy (15.1 +/- 2.3) (n = 16) (p < 0.001), coeliac children on a gluten-free diet without enteropathy (14.2 +/- 1.6) (n = 14) (p < 0.001), coeliac children on gluten challenge with enteropathy (14.1 +/- 2.1) (n = 12) (p < 0.001) and coeliac children on gluten challenge without enteropathy (13.8 +/- 1.9) (n = 6) (p < 0.005).

Conclusion: Serum zinc concentration is decreased in untreated coeliac children with enteropathy and normalizes on gluten-free diet. A low serum zinc value in a child being investigated for possible CD on clinical grounds can thus be used as a complementary marker for enteropathy indicating further investigation with small bowel biopsy. The hypothetical role of zinc in the pathogenesis of CD is discussed.

Place, publisher, year, edition, pages
2009. Vol. 98, no 2, 343-345 p.
Keyword [en]
Coeliac disease, Serum zinc
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16635DOI: 10.1111/j.1651-2227.2008.01085.xOAI: oai:DiVA.org:liu-16635DiVA: diva2:159547
Available from: 2009-02-08 Created: 2009-02-06 Last updated: 2009-08-19

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Högberg, LottaSundqvist, TommyStenhammar, Lars

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