Recent-onset rheumatoid arthritis: A 1-year observational study of correlations between health‐related quality of life and clinical/laboratory data
2005 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, Vol. 37, no 3, 159-165 p.Article in journal (Refereed) Published
Objective: To analyse correlations within and between clinical/laboratory assessments and health-related quality of life variables for recent-onset rheumatoid arthritis at the time of diagnosis and 12 months later.
Methods: A total of 297 patients with recent-onset (?12 months) rheumatoid arthritis were included at diagnosis and followed up for 12 months. Clinical/laboratory assessment was performed by erythrocyte sedimentation rate, C-reactive protein, 28-joint count of tender/swollen joints, physician's global assessment, grip force, grip ability, functional impairment and walking speed. The self-reported health-related quality of life included symptoms (pain, morning stiffness), patients estimated general health, Health Assessment Questionnaire and SF-36.
Results: All tested variables improved within 6 months of diagnosis and then remained stable but still affected at the 12-month follow-up. Multivariate correlations between clinical/laboratory variables and health-related quality of life were weak. At inclusion, clinical/laboratory assessments explained 18% of health-related quality of life at the same time-point and predicted 7% of the variation in health-related quality of life after 12 months.
Conclusion: The time-course followed similar patterns for most variables, but only a small part of the variation in health-related quality of life was explained or predicted by the clinical/laboratory variables. This implies that health-related quality of life adds important information to clinical/laboratory assessments in clinical practice and should be considered in goal setting together with clinical/laboratory assessment in order to optimize healthcare and outcome.
Place, publisher, year, edition, pages
Taylor & Francis , 2005. Vol. 37, no 3, 159-165 p.
Outcome, early rheumatoid arthritis, health‐related quality of life, HAQ, SF‐36, grip force, walking speed
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16666DOI: 10.1080/16501970410023344OAI: oai:DiVA.org:liu-16666DiVA: diva2:159748