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A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, ANOPIVA US.ORCID iD: 0000-0003-2888-4111
Helsinki Univ Hosp, Finland; Univ Helsinki, Finland.
Copenhagen Univ Hosp, Denmark.
Helse Bergen Hlth Trust, Norway.
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2022 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 66, no 1, p. 56-64Article in journal (Refereed) Published
Abstract [en]

Background We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, Iceland, Norway and Sweden. Methods Representatives from the national ICU registries for each of the five countries provided clinical data and a description of the strategies to allocate ICU resources and increase the ICU capacity during the pandemic. All adult patients admitted to the ICU for COVID-19 disease during the first wave of COVID-19 were included. The clinical characteristics, ICU management and outcomes of individual countries were described with descriptive statistics. Results Most countries more than doubled their ICU capacity during the pandemic. For patients positive for SARS-CoV-2, the ratio of requiring ICU admission for COVID-19 varied substantially (1.6%-6.7%). Apart from age (proportion of patients aged 65 years or over between 29% and 62%), baseline characteristics, chronic comorbidity burden and acute presentations of COVID-19 disease were similar among the five countries. While utilization of invasive mechanical ventilation was high (59%-85%) in all countries, the proportion of patients receiving renal replacement therapy (7%-26%) and various experimental therapies for COVID-19 disease varied substantially (e.g. use of hydroxychloroquine 0%-85%). Crude ICU mortality ranged from 11% to 33%. Conclusion There was substantial variability in the critical care response in Nordic ICUs to the first wave of COVID-19 pandemic, including usage of experimental medications. While ICU mortality was low in all countries, the observed variability warrants further attention.

Place, publisher, year, edition, pages
WILEY , 2022. Vol. 66, no 1, p. 56-64
Keywords [en]
COVID-19, mortality, Nordic, SARS-CoV2
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-180269DOI: 10.1111/aas.13983ISI: 000702990200001PubMedID: 34570897OAI: oai:DiVA.org:liu-180269DiVA, id: diva2:1603129
Note

Funding Agencies|NordForsk (Nordic COVID-19 Activities); Finnish Society of Intensive Care

Available from: 2021-10-14 Created: 2021-10-14 Last updated: 2023-05-04

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Chew, MichelleWalther, Sten
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Division of Clinical Chemistry and PharmacologyFaculty of Medicine and Health SciencesANOPIVA USDepartment of Thoracic and Vascular SurgeryDepartment of Health, Medicine and Caring Sciences
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