Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitorShow others and affiliations
2022 (English)In: Nature Biomedical Engineering, E-ISSN 2157-846X, Vol. 6, no 6, p. 741-753Article in journal (Refereed) Published
Abstract [en]
Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm(3) thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-mu s pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves. An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.
Place, publisher, year, edition, pages
NATURE PORTFOLIO , 2022. Vol. 6, no 6, p. 741-753
National Category
Bioengineering Equipment
Identifiers
URN: urn:nbn:se:liu:diva-182005DOI: 10.1038/s41551-021-00817-7ISI: 000730885500001PubMedID: 34916610OAI: oai:DiVA.org:liu-182005DiVA, id: diva2:1623075
Note
Funding Agencies|European Research Council (ERC) under the European UnionEuropean Research Council (ERC) [949191]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation; Swedish Research Council (Vetenskapsradet)Swedish Research Council [2018-04505]; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research; Columbia University, School of Engineering and Applied Science; Columbia University Medical Center, Department of Neurology and Institute for Genomic Medicine; MEYS CR [LM2018110]; Croatian Science Foundation [UIP-2019-04-1753]; Croatian Government; European Union through the European Regional Development Fund - Competitiveness and Cohesion Operational Programme [KK.01.1.1.02.0013]; QuantiXLie Center of Excellence; European Union through the European Regional Development Fund - the Competitiveness and Cohesion Operational Programme [KK.01.1.1.01.0004]; Center of Excellence for Advanced Materials and Sensors, Croatia; project CeNIKS
2021-12-272021-12-272024-01-10