A preliminary study of modeling and simulation in individualized drug dosage – azathioprine on inflammatory bowel disease
2007 (English)In: SIMS 2006: Proceedings of the 47th Conference on Simulation and Modelling, Helsinki, Finland, Helsinki: Kopio Niini Oy , 2007, 216-220 p.Conference paper (Refereed)
Individualized drug dosage based on population pharmacokinetic/dynamic models is an important future technology used to reduce or eliminate side effects of certain drugs, e.g. cancer drugs. In this paper we report preliminary results from work-in-progress: a simplified linear model of the metabolism of a cancer treatment drug was estimated from experimental data. The model was then validated against the same data as a test of the adequacy of the model structure. From this investigation it became apparent that the model structure could not be used due to its inability to recreate the dynamic properties of the system.
Place, publisher, year, edition, pages
Helsinki: Kopio Niini Oy , 2007. 216-220 p.
azathioprine, inflammatory bowel disease, pharmacokinetic
Bioinformatics (Computational Biology)
IdentifiersURN: urn:nbn:se:liu:diva-10250ISBN: 9525183300OAI: oai:DiVA.org:liu-10250DiVA: diva2:16999