Tumour growth fraction and apoptosis in salivary gland acinic cell carcinomas: Prognostic implications of Ki-67 and bcl-2 expression and of in situ end labelling (TUNEL)
1997 (English)In: The Journal of Pathology, ISSN 0031-3025 (print) 1465-3931 (online), Vol. 181, no 3, 323-329 p.Article in journal (Refereed) Published
bcl-2 protein and Ki-67 (MIB-1) were studied in 32 acinic cell carcinomas (ACCs), all with a minimum of 5 years' clinical follow-up. Tumour apoptosis was evaluated by TdT dUTP nick end labelling (TUNEL) and by morphological criteria. Five patients died of their disease. Patients with stage I tumours had significantly better survival compared with other stages (P<0·05). Patients with MIB-1-negative tumours had significantly better survival than patients with MIB-1-positive tumours (P=0·05). This study confirms a previous report that MIB-1 is an independent prognostic factor for survival in patients with ACC. Stage I tumours had high expression of bcl-2 protein, but there was no difference when compared with other stages. TUNEL positivity was most prevalent in stage I tumours, compared with stages II, III, and IV (P<0·05), probably indicating more apoptosis. This could imply a capacity of stage I tumours ('early tumours') for early selection of tumour cells for elimination by apoptosis. There was no significant difference between expression of bcl-2 and TUNEL, between these parameters and clinical outcome, or between any parameter and morphological subclassification. We conclude that MIB-1 has prognostic value in ACC. Clinical staging, bcl-2, and TUNEL are also potentially useful as prognostic markers.
Place, publisher, year, edition, pages
1997. Vol. 181, no 3, 323-329 p.
apoptosis, bcl-2, TUNEL, end labelling, salivary neoplasm, Ki-67
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-12804DOI: 10.1002/(SICI)1096-9896(199703)181:3<323::AID-PATH780>3.0.CO;2-KOAI: oai:DiVA.org:liu-12804DiVA: diva2:17089