Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue
1997 (English)In: European Journal of Cancer, ISSN 0959-8049, Vol. 33, no 11, 1860-1864 p.Article in journal (Refereed) Published
Metallothionein (MT) is a chelator present in myoepithelial cells, whilst the Fas-receptor (APO-1, CD95) has been described primarily in human T Jurkat cells. 20 cases of carcinoma of the tongue were investigated immunocytochemically with regard to MT, Fas and Bcl-2. In normal oral squamous epithelium, MT is located in the basal/parabasal dividing cells only. In well-differentiated nests of carcinomas, MT is observed almost entirely in peripherally located cells. In situ end-labelling indicates apoptosis in the centre of these nests, but not in the peripheral areas. Less-differentiated areas show more general MT-positivity, but little apoptosis. All 24 tumours are Fas-positive, but normal epithelia are mainly negative (P< 0.0001). Bcl-2 protein was sparse in the tumours compared with MT and Fas (P< 0.0001). We thus suggest that MT, possibly due to its chelating properties, may contribute to delaying cells entering apoptosis, both in normal epithelium near the base and in less-differentiated regions of carcinoma. Moreover, Fas may be present in cells of human malignancies, as well as those of established malignant cell lines.
Place, publisher, year, edition, pages
1997. Vol. 33, no 11, 1860-1864 p.
apoptosis, Bcl-2, carcinoma squamous cell, chelator, Fas, metallothionein, tongue
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-12805DOI: 10.1016/S0959-8049(97)00216-5OAI: oai:DiVA.org:liu-12805DiVA: diva2:17090