As we move through the 21st century one of the most important health issues facing both men and women is to understand how social forces shape biology and human health, which requires considering gender as well as biological sex. While epigenetics, the study of how stress modifies gene expression, is one of the most powerful explanations for how the gender and sex might interact to produce the phenotype, we should also consider how social location, geography, life circumstances, traditions, and health-care practices—in other words, experience—influence the creation and shaping of brain circuits. This requires multidisciplinary thinking which I believe is a key component to gender-specific medicine (GSM). In this chapter I discuss some of the mechanisms, challenges, and supports I have received in pursuing a teaching and research program promulgating this type of multidisciplinarity. The field’s strides have been great but the journey continues.