Presence of Poorly Differentiated Component Correlated with Submucosal Invasion in the Early Diffuse-type Gastric Cancer
2008 (English)In: HEPATO-GASTROENTEROLOGY, ISSN 0172-6390 , Vol. 55, no 88, 2264-2268 p.Article in journal (Refereed) Published
Background/Aims. Diffuse-type gastric carcinoma is associated with a poor prognosis. However, the clinical behavior of diffuse-type gastric cancer is not fully understood. The aim of this study is to distinguish the behaviors of early diffuse-type gastric carcinomas by sub classifying tumors according to their histologic features.
Methodology. A total of 114 cases of diffuse-type early gastric cancer were studied retrospectively. We analyzed and compared the resected cancer specimens according to the histologic components: as poorly differentiated adenocarcinoma component-present (poor+) versus poorly differentiated adenocarcinoma component-absent (poor-). Helicobacter pylori status was evaluated by Giemsa staining and IgG serology. We assessed the degree of cancer invasion and compared back-ground status of gastritis in accordance with the updated Sydney System criteria and serologic markers.
Results. In comparison to the poor+ cancers, the poor- cancers had a significantly larger portion of cells confined to the mucosa (p=0.002). Only 8 of the 114 cases were regarded as H. pylori-negative. Although we could not detect any serologic markers specific for gastritis with poor+ cancer, but the serum levels of gastrin was slightly higher in patients with poor+ cancers than in those with poor- cancers.
Conclusions. The biologic behavior of poor+ gastric carcinoma is worse than that of poor- carcinoma. There is a close relation between H. pylori infection and carcinogenesis of poorly differentiated adenocarcinoma.
Place, publisher, year, edition, pages
2008. Vol. 55, no 88, 2264-2268 p.
Gastric cancer, Helicobacter pylori, Gastritis, Diffuse type, Serologic markers
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16866OAI: oai:DiVA.org:liu-16866DiVA: diva2:174414