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Putting the pieces together in diabetes research: Towards a hierarchical model of whole-body glucose homeostasis
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
2009 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 36, no 1, 91-104 p.Article in journal (Refereed) Published
Abstract [en]

Type 2 diabetes is one of the most widespread and rapidly spreading diseases world-wide and has been subject of extensive research efforts. However, understanding the molecular basis of the disease is increasing piecemeal and a consensus regarding the overall picture of normal metabolic regulation and malfunction in diabetes has not emerged. A systems biology approach, combining mathematical modelling with simultaneous high-throughput measurements, can be of considerable help. On the whole-body level, this has been done in pharmacokinetic and pharmacodynamic models, which recently have started to mature into more physiologically realistic organ-based models. At the other end of the spectrum, detailed models for crucial cellular processes are starting to mature into complete modules that potentially can be fitted into such whole-body organ-based models. The result of such a merge is a multi-level hierarchical model, which is a model type that has been common in technical systems. In this review, we report and exemplify some of the recent progress that has been made to achieve such a hierarchical model, and we argue why it is only through such a model that a Complete picture of diabetes mellitus can be obtained.

Place, publisher, year, edition, pages
2009. Vol. 36, no 1, 91-104 p.
Keyword [en]
Systems biology, Glucose homeostasis, PKPD, Hierarchical, Type 2 diabetes
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-16871DOI: 10.1016/j.ejps.2008.10.027OAI: oai:DiVA.org:liu-16871DiVA: diva2:174419
Available from: 2009-02-22 Created: 2009-02-20 Last updated: 2017-12-13

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Cedersund, GunnarStrålfors , Peter

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  • de-DE
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