Putting the pieces together in diabetes research: Towards a hierarchical model of whole-body glucose homeostasis
2009 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, Vol. 36, no 1, 91-104 p.Article in journal (Refereed) Published
Type 2 diabetes is one of the most widespread and rapidly spreading diseases world-wide and has been subject of extensive research efforts. However, understanding the molecular basis of the disease is increasing piecemeal and a consensus regarding the overall picture of normal metabolic regulation and malfunction in diabetes has not emerged. A systems biology approach, combining mathematical modelling with simultaneous high-throughput measurements, can be of considerable help. On the whole-body level, this has been done in pharmacokinetic and pharmacodynamic models, which recently have started to mature into more physiologically realistic organ-based models. At the other end of the spectrum, detailed models for crucial cellular processes are starting to mature into complete modules that potentially can be fitted into such whole-body organ-based models. The result of such a merge is a multi-level hierarchical model, which is a model type that has been common in technical systems. In this review, we report and exemplify some of the recent progress that has been made to achieve such a hierarchical model, and we argue why it is only through such a model that a Complete picture of diabetes mellitus can be obtained.
Place, publisher, year, edition, pages
2009. Vol. 36, no 1, 91-104 p.
Systems biology, Glucose homeostasis, PKPD, Hierarchical, Type 2 diabetes
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16871DOI: 10.1016/j.ejps.2008.10.027OAI: oai:DiVA.org:liu-16871DiVA: diva2:174419