Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome
2009 (English)In: Clinica Chimica Acta, ISSN 0009-8981, Vol. 400, no 1-2, 128-131 p.Article in journal (Refereed) Published
Introduction: Inflammation is pivotal in atherosclerosis. Minor C-reactive protein (CRP) response reflects low-grade vascular inflammation and the high-sensitivity CRP test with levels >= 3.0 mg/l predicts coronary vascular events and survival in angina pectoris as well as in healthy subjects. We and others recently reported autoantibodies against monomeric CRP (anti-CRP) in rheumatic conditions, e.g. systemic lupus erythematosus (SLE), and a connection between anti-CRP and cardiovascular disease in SLE has been suggested.
Patients and methods: Anti-CRP serum levels were determined with ELISA in 140 individuals; 50 healthy controls and 90 patients with angiographically verified coronary artery disease of which 40 presented with acute coronary syndrome (ACS) and 50 with stable angina pectoris (SA).
Results: Significantly lower anti-CRP levels were observed in ACS compared to SA and controls (p=0.019). ACS patients, who had not been prescribed statins before their respective cardiovascular event, had lower anti-CRP (p = 0.049). BMI correlated directly to anti-CRP levels in cross section analysis (p = 0.043), but there was no association between anti-CRP and smoking or cholesterol.
Discussion: In ACS, it is plausible that ruptured plaques and inflamed tissue may be more prone to opsonization by monomeric CRP leading to consumption of anti-CRP, Hypothetically, surface-bound anti-CRP could thereby enhance the local inflammation in plaques.
Place, publisher, year, edition, pages
2009. Vol. 400, no 1-2, 128-131 p.
Anti-CRP antibody, Atherosclerosis, C-reactive protein, Coronary artery disease
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16881DOI: 10.1016/j.cca.2008.10.002OAI: oai:DiVA.org:liu-16881DiVA: diva2:174428
Jonas Wetterö, Lennart Nilsson, Lena Jonasson and Christoffer Sjöwall, Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome, 2009, CLINICA CHIMICA ACTA, (400), 1-2, 128-131.
Copyright: Elsevier Science B.V., Amsterdam.