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Overrepresentation of HLA-DQ2 in Small Intestinal Neuroendocrine Tumor Patients
Department of Surgery, Ryhov County Hospital, Jönköping, Sweden.ORCID iD: 0000-0001-6808-371x
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.
Department of Medicine, Kalmar County Hospital, Kalmar, Sweden.
Department of Oncology, Linköping University Hospital, Linköping, Sweden.
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2014 (English)In: Journal of Gastrointestinal Cancer, ISSN 1941-6628, E-ISSN 1941-6636, Vol. 45, no 4, p. 472-475Article in journal (Refereed) Published
Abstract [en]

Purpose: To investigate whether celiac disease risk haplotypes HLA-DQ2 and DQ8 also increase the risk for developing small intestinal neuroendocrine tumor (SI-NET).

Methods: Thirty-five patients with serotonin-producing jejunal and ileal SI-NET were examined with HLA-DQ genotyping and serology for IgA anti-tissue transglutaminase (tTG) antibodies.

Results: Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice the frequency of the general population (P < 0.001). In particular DQ2 was overrepresented (P = 0.013). Gender, age, disease stage, histopathological grade, or multifocality of primary tumor did not differ between patients with DQ2 or DQ8 and patients with other HLA-DQ haplotypes. No patient in the study was diagnosed with celiac disease (latent or symptomatic) as anti-tTG antibodies were negative in all 35.

Conclusion: HLA-DQ haplotypes associated with celiac disease are overrepresented also in patients with SI-NET, in particular HLA-DQ2.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 45, no 4, p. 472-475
Keywords [en]
Carcinoid; Celiac disease; Gastro-enteropancreatic neuroendocrine tumor; HLA-DQ; Neuroendocrine tumor; Small intestinal neuroendocrine tumor
National Category
Endocrinology and Diabetes Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-192902DOI: 10.1007/s12029-014-9651-6OAI: oai:DiVA.org:liu-192902DiVA, id: diva2:1749086
Available from: 2023-04-05 Created: 2023-04-05 Last updated: 2023-04-05

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