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High Proton Relaxivity for Gadolinium Oxide Nanoparticles
Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-7171-5383
Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics. Linköping University, The Institute of Technology.
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2006 (English)In: Magnetic Resonance Materials in Physics, Biology and Medicine, ISSN 0968-5243, E-ISSN 1352-8661, Vol. 19, no 4, 180-186 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Nanosized materials of gadolinium oxide can provide high-contrast enhancement in magnetic resonance imaging (MRI). The objective of the present study was to investigate proton relaxation enhancement by ultrasmall (5 to 10 nm) Gd2O3 nanocrystals.

Materials and methods: Gd2O3 nanocrystals were synthesized by a colloidal method and capped with diethylene glycol (DEG). The oxidation state of Gd2O3 was confirmed by X-ray photoelectron spectroscopy. Proton relaxation times were measured with a 1.5-T MRI scanner. The measurements were performed in aqueous solutions and cell culture medium (RPMI).

Results: Results showed a considerable relaxivity increase for the Gd2O3–DEG particles compared to Gd-DTPA. Both T 1 and T 2 relaxivities in the presence of Gd2O3–DEG particles were approximately twice the corresponding values for Gd–DTPA in aqueous solution and even larger in RPMI. Higher signal intensity at low concentrations was predicted for the nanoparticle solutions, using experimental data to simulate a T1-weighted spin echo sequence.

Conclusion: The study indicates the possibility of obtaining at least doubled relaxivity compared to Gd–DTPA using Gd2O3–DEG nanocrystals as contrast agent. The high T 1 relaxation rate at low concentrations of Gd2O3 nanoparticles is very promising for future studies of contrast agents based on gadolinium-containing nanocrystals.

Place, publisher, year, edition, pages
2006. Vol. 19, no 4, 180-186 p.
Keyword [en]
Gd2O3, Nanoparticle, Contrast agent, Relaxivity, MRI
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-12943DOI: 10.1007/s10334-006-0039-xISI: 000241584400002OAI: oai:DiVA.org:liu-12943DiVA: diva2:17497
Available from: 2008-02-21 Created: 2008-02-21 Last updated: 2017-12-13
In thesis
1. MRI Contrast Enhancement using Gd2O3 Nanoparticles
Open this publication in new window or tab >>MRI Contrast Enhancement using Gd2O3 Nanoparticles
2008 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

There is an increasing interest for nanomaterials in biomedical applications and in this work, nanoparticles of gadolinium oxide (Gd2O3) have been investigated as a novel contrast agent for Magnetic Resonance Imaging (MRI). Relaxation properties have been studied in aqueous solutions as well as in cell culture medium and the nanoparticles have been explored as cell labeling agents. The fluorescent properties of the particles were used to visualize the internalization in cells and doped particles were also investigated as a multimodal agent that could work as a fluorescent marker for microscopy and as a contrast enhancer for MRI.

Results show that in aqueous solutions, there is a twofold increase in relaxivity for Gd2O3 compared to commercial agent Gd-DTPA. In cell culture medium as well as in cells, there is a clear T1 effect and a distinct increase in signal intensity in T1-mapped images. Fluorescent studies show that the Gd2O3 nanoparticles doped with 5% terbium have interesting fluorescent properties and that these particles could work as a multimodal contrast agent.

This study shows that Gd2O3 nanoparticles possess excellent relaxation properties that are retained in more biological environments. Gd2O3 particles are suitable as a T1 contrast agent, but seem also be adequate for T2 enhancement in for instance cell labeling experiments.

Place, publisher, year, edition, pages
Universitetsbibliotek, 2008. 116 p.
Series
Linköping Studies in Health Sciences. Thesis, ISSN 1100-6013 ; 85
Keyword
nanoparticles, gadolinium oxide, magnetic resonance imaging, contrast agent
National Category
Clinical Science
Identifiers
urn:nbn:se:liu:diva-11041 (URN)978-91-7393-966-9 (ISBN)
Presentation
2008-03-07, Conrad, Huvudblocket, plan 11, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Supervisors
Available from: 2008-02-21 Created: 2008-02-21 Last updated: 2013-09-04
2. MRI Contrast Enhancement and Cell Labeling using Gd2O3 Nanoparticles
Open this publication in new window or tab >>MRI Contrast Enhancement and Cell Labeling using Gd2O3 Nanoparticles
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There is an increasing interest for nanomaterials in bio-medical applications and in this work, nanoparticles of gadolinium oxide (Gd2O3 ) have been investigated as a novel contrast agent for magnetic resonance imaging (MRI). Relaxation properties have been studied in aqueous solutions as well as in cell culture medium and the nanoparticles have been explored as cell labeling agents. The fluorescent properties of the particles were used to visualize the internalization in cells and doped particles were investigated as a multimodal agent that could work as a fluorescent marker for microscopy and as a contrast enhancer for MRI. Fluorescent studies show that the Gd2O3 nanoparticles doped with 5% terbium have interesting fluorescent properties and that these particles could work as such multimodal contrast agent. Relaxivity measurements show that in aqueous solutions, there is a twofold increase in relaxivity for Gd2O3 compared to commercial agent Gd-DTPA. In cell culture medium as well as in cells, there is a clear T1 effect and an increase in signal intensity in T1-mapped images. The cellular uptake of Gd2O3 nanoparticles were increased with the use of transfection agent protamine sulfate. This work shows that Gd2O3 nanoparticles possess good relaxation properties that are retained in different biological environments. Gd2O3 particles are suitable as a T1 contrast agent, but seem also be adequate for T2 enhancement in forinstance cell labeling experiments.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2011. 73 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1230
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-68802 (URN)978-91-7393-215-8 (ISBN)
Public defence
2011-06-08, Wrannesalen, Universitetssjukhuset, CMIV, Campus US, Linköpings universitet, Linköping, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2011-06-07 Created: 2011-06-07 Last updated: 2013-09-05Bibliographically approved

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Engström, MariaKlasson, AnnaPedersen, HenrikVahlberg, CecilliaKäll, Per-OlovUvdal, Kajsa

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