Early effects of IL-6 receptor inhibition on bone homeostasis: a pilot study in women with rheumatoid arthritisShow others and affiliations
2011 (English)In: Clinical and Experimental Rheumatology, ISSN 0392-856X, E-ISSN 1593-098X, Vol. 29, no 6, p. 921-925Article in journal (Refereed) Published
Abstract [en]
Objectives: A critical role of interleukin-6 (IL-6) in bone homeostasis has been suggested in experimental studies. We examined whether inhibition of IL-6 receptor in patients with rheumatoid arthritis (RA) results in early alterations of circulating markers of bone remodelling.
Methods: Circulating levels of osteoprotegerin, receptor activator of nuclear factor-kappaB ligand (RANKL), Wnt signalling pathway inhibitors Dickkopf-1 (Dkk-1) and sclerostin, markers of bone resorption (C-terminal cross-linking telopeptide of collagen type-I (CTX), tartrate-resistant acid phosphatase isoform-5b) and bone formation (bone-specific alkaline-phosphatase, osteocalcin) were examined in 22 women with active RA before and after two monthly infusions of tocilizumab (8mg/kg each); 'healthy', non-osteopenic, 1:1 age-matched women served as controls.
Results: At baseline, osteoprotegerin/RANKL ratio in patients was lower than controls by 5-fold; circulating osteoprotegerin correlated negatively with corresponding 28-joint-count disease activity scores and circulating RANKL correlated positively with C-reactive protein. Also, Dkk-1, sclerostin, CTX and osteocalcin levels were higher in RA than controls. After two months, osteoprotegerin/RANKL ratio increased, Dkk-1 decreased and sclerostin increased comparing to baseline; other markers did not change significantly. Increases of osteoprotegerin/RANKL ratio were more prominent in 10 patients who achieved remission or low disease activity after tocilizumab than in 12 patients who did not. In contrast, the significant alterations of both Wnt inhibitors were comparable between these patient subgroups.
Conclusions: Anti-IL-6 therapy induced suppression of the inflammatory response affects rapidly the disrupted bone homeostasis in active RA. An additional, possibly specific, effect of IL-6 receptor inhibition on bone remodelling in humans should be further examined.
Place, publisher, year, edition, pages
Pisa, Italy: Clinical and Experimental Rheumatology , 2011. Vol. 29, no 6, p. 921-925
Keywords [en]
tocilizumab; receptor activator of nuclear factor kappaB ligand (RANKL); dickkopf-1; sclerostin
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-193049ISI: 000300032600004PubMedID: 22032557Scopus ID: 2-s2.0-84857534016OAI: oai:DiVA.org:liu-193049DiVA, id: diva2:1749756
2023-04-112023-04-112024-01-10Bibliographically approved