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Comprehensive chemical characterization of indoor dust by target, suspect screening and nontarget analysis using LC-HRMS and GC-HRMS
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID iD: 0000-0001-5583-8976
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID iD: 0000-0001-7555-142X
Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID iD: 0000-0002-5729-1908
2021 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 276, article id 116701Article in journal (Refereed) Published
Abstract [en]

Since humans spend more than 90% of their time in indoor environments, indoor exposure can be an important non-dietary pathway to hazardous organic contaminants. It is thus important to characterize the chemical composition of indoor dust to assess the total contaminant exposure and estimate human health risks. The aim of this investigation was to perform a comprehensive chemical characterization of indoor dust. First, the robustness of an adopted extraction method using ultrasonication was evaluated for 85 target compounds. Thereafter, a workflow combining target analysis, suspect screening analysis (SSA) and nontarget analysis (NTA) was applied to dust samples from different indoor environments. Chemical analysis was performed using both gas chromatography and liquid chromatography coupled with high resolution mass spectrometry. Although suppressing matrix effects were prominent, target analysis enabled the quantification of organophosphate/brominated flame retardants (OPFRs/BFRs), liquid crystal monomers (LCMs), toluene diisocyanate, bisphenols, pesticides and tributyl citrate. The SSA confirmed the presence of OPFRs but also enabled the detection of polyethylene glycols (PEGs) and phthalates/parabens. The combination of hierarchical cluster analysis and scaled mass defect plots in the NTA workflow confirmed the presence of the above mentioned compounds, as well as detect other contaminants such as tetrabromobisphenol A, triclocarban, diclofenac and 3,5,6-trichloro-2-pyridinol, which were further confirmed using pure standards.

Place, publisher, year, edition, pages
Springer , 2021. Vol. 276, article id 116701
Keywords [en]
High resolution mass spectrometry, Indoor dust, Nontarget screening analysis, Organic contaminants, Suspect screening analysis
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-193748DOI: 10.1016/j.envpol.2021.116701ISI: 000630774100040PubMedID: 33621737Scopus ID: 2-s2.0-85101342647OAI: oai:DiVA.org:liu-193748DiVA, id: diva2:1757463
Funder
Swedish Environmental Protection Agency, NV-02846-19Knowledge Foundation, 20180129Available from: 2023-05-16 Created: 2023-05-16 Last updated: 2023-05-29

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Dubocq, FlorianKärrman, AnnaWang, Thanh

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