Platelet concentrate injection improves Achilles tendon repair in rats
2004 (English)In: Acta Orthopaedica Scandinavica, ISSN 1745-3674 (print), 1745-3682 (online), Vol. 75, no 1, 93-99 p.Article in journal (Refereed) Published
Background:Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair.
Experiment and findings: We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6h, a platelet concentrate was injected percutaneously into the hematoma. This increased tendon callus strength and stiffness by about 30 % after 1 week, which persisted for as long as 3 weeks after the injection. At this time, the mechanical testing indicated an improvement in material characteristics - i.e., greater maturation of the tendon callus. This was confirmed by blinded histological scoring.
Interpretation: Platelet concentrate may prove useful for the treatment of Achilles tendon ruptures.
Place, publisher, year, edition, pages
2004. Vol. 75, no 1, 93-99 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13012DOI: 10.1080/759369155OAI: oai:DiVA.org:liu-13012DiVA: diva2:17670