liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Aspects on wall properties of the brachial artery in man: with special reference to SLE and insulin-dependent diabetes mellitus
Linköping University, Department of Medicine and Health Sciences. Linköping University, Faculty of Health Sciences.
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The mechanical properties of the arterial wall are of great importance for blood pressure regulation and cardiac load. With increasing age, large arteries are affected by increased wall stiffness. Furthermore, atherosclerotic manifestations may increase the stiffness even further, both processes acting as independent cardiovascular risk factors affecting the arterial system in a heterogeneous way.

The aims of this thesis was to characterize the local mechanical properties of brachial artery (BA) with the aid of ultrasound technique and to evaluate the influence of 1) age, gender, sympathetic stimulation and examination site; 2) type 1 diabetes (DM) and its association to circulatory biomarkers; and 3) to evaluate the general properties of the arterial system with the aid of pulse wave velocity (PWV) as well as pulse wave analysis (PWA) in systemic lupus erythematosus (SLE) and correlate the findings to disease activity and circulatory biomarkers.

In the most proximal arterial segment of the upper arm a pronounced age-related decrease in wall distensibility, increase in intima-media thickness (IMT), and a slight increase in diameter were seen. Sympathetic stimulation had no influence on wall mechanics. More distally in BA, no change in diameter, and only minor increase in IMT and decrease in distensibility were seen. No gender differences were found. These findings suggest that the principle transit zone between elastic and muscular artery behaviour is located in the proximal part of the upper arm.

Women with uncomplicated insulin-dependent DM had similar diameter, IMT and distensibility in their distal BA as controls, whereas flow-mediated dilatation (FMD) was slightly, and nitrate mediated dilatation (NMD) markedly reduced. NMD was negatively correlated with higher HbA1c levels. Vascular smooth muscle cell function seems to be an early manifestation of vascular disease in women with DM, influenced by long-term hyperglycaemia.

Women with SLE had increased aortic PWV compared to controls, a finding positively associated with increased levels of complement factor 3 (C3), but not with disease activity. The increased stiffness of central arteries may be one factor contributing to the increased cardiovascular risk seen in SLE.

Place, publisher, year, edition, pages
Institutionen för medicin och hälsa , 2008.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1042
Keyword [en]
Arterial wall, atherosclerotic, brachial artery (BA), type 1 diabetes, ulse wave velocity (PWV), pulse wave analysis (PWA), intima-media thickness (IMT), nitrate mediated dilatation (NMD)
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-11273ISBN: 978-91-7393-982-9 (print)OAI: oai:DiVA.org:liu-11273DiVA: diva2:17694
Public defence
2008-04-11, Elsa Brändström, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2008-03-13 Created: 2008-03-13 Last updated: 2017-03-27
List of papers
1. Age affects proximal brachial artery stiffness: differential behaviour within the length of the brachial artery?
Open this publication in new window or tab >>Age affects proximal brachial artery stiffness: differential behaviour within the length of the brachial artery?
Show others...
2003 (English)In: Ultrasound in Medicine and Biology, ISSN 0301-5629, Vol. 29, no 8, 1115-1121 p.Article in journal (Refereed) Published
Abstract [en]

With increasing age, the diameter of central elastic arteries increases, whereas their distensibility decreases. The purpose of this study was to investigate the mechanical properties of the proximal brachial artery in relation to age and gender. Distensibility coefficient (DC), stiffness and compliance coefficient (CC) were calculated in 136 healthy males and females (range 9-82 y) using echo-tracking sonography. CC decreased with age in both genders, but CC was higher in males. Stiffness increased and DC decreased with age in an exponential manner, without any differences between genders. In conclusion, as in central elastic arteries, the distensibility of the proximal brachial artery decreases with age, in contrast to earlier reports on the muscular distal brachial artery. This may imply that the transition between elastic and muscular artery behavior is within the length of the brachial artery. In future studies using the brachial artery, the examination site needs to be defined.

Keyword
Brachial artery, Ageing, Gender, Echo-tracking, Distensibility, Stiffness
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13028 (URN)10.1016/S0301-5629(03)00052-8 (DOI)
Available from: 2008-03-13 Created: 2008-03-13 Last updated: 2017-03-27
2. The effect of sympathetic stimulation on proximal brachial artery mechanics in humans: differential behaviour within the length of the brachial artery
Open this publication in new window or tab >>The effect of sympathetic stimulation on proximal brachial artery mechanics in humans: differential behaviour within the length of the brachial artery
2004 (English)In: Acta physiologica Scandinavica, Vol. 182, no 1, 21-27 p.Article in journal (Refereed) Published
Abstract [en]

Aims: The mechanical properties of arteries play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the proximal brachial artery was analysed in 18 healthy volunteers, nine young (25 ± 2 years) and nine elderly (69 ± 2 years).

Methods: A non-invasive ultrasonic echo-tracking system for measurement of systolic/diastolic variation of the proximal brachial artery diameter in combination with intra-arterial pressure measurements was used to determine wall mechanics. The pressure–diameter (P–D) relationship, distensibility coefficient (DC), compliance coefficient (CC) and stiffness(β) were obtained at rest and during sympathetic stimulation induced by lower body negative pressure (LBNP).

Results: The peripheral vascular resistance increased by 100 and 72%, respectively in the young and elderly during LBNP (P < 0.001). Simultaneously, the mechanical properties of the proximal brachial artery remained unaltered, as estimated from both P–D relationship and stiffness in young (β-index rest: 5.2 ± 0.9, LBNP: 5.5 ± 1.3, NS) as well as elderly (β-index rest: 13.6 ± 4.6, LBNP: 16.1 ± 4.7, NS).

Conclusions: LBNP-induced sympathetic activation does not change proximal brachial artery mechanics, in contrast to earlier reports on the muscular distal brachial artery. This may imply that the transition between elastic and muscular artery behaviour is within the length of the brachial artery, where the site of transition from elastic to muscular wall structure needs to be specified in future studies.

Keyword
ageing, brachial artery, distensibility, lower body negative pressure, stiffness, sympathetic stimulation
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13029 (URN)10.1111/j.1365-201X.2004.01336.x (DOI)
Available from: 2008-03-13 Created: 2008-03-13 Last updated: 2017-03-27
3. Increased aortic pulse wave velocity in middle-aged women with systemic lupus erythematosus
Open this publication in new window or tab >>Increased aortic pulse wave velocity in middle-aged women with systemic lupus erythematosus
Show others...
2006 (English)In: Lupus, ISSN 0961-2033, Vol. 15, no 10, 644-650 p.Article in journal (Refereed) Published
Abstract [en]

Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls.

Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3).

Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.

Keyword
arteries, blood pressure, elasticity, pulse, SLE, women
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13030 (URN)10.1177/0961203306071402 (DOI)
Available from: 2008-03-13 Created: 2008-03-13 Last updated: 2017-03-27
4. Impaired endothelial independent vasodilatation in women with type 1 diabetes
Open this publication in new window or tab >>Impaired endothelial independent vasodilatation in women with type 1 diabetes
Show others...
2008 (English)Manuscript (preprint) (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13031 (URN)
Available from: 2008-03-13 Created: 2008-03-13 Last updated: 2017-03-27Bibliographically approved

Open Access in DiVA

cover(1537 kB)46 downloads
File information
File name COVER01.pdfFile size 1537 kBChecksum MD5
293ab7edcc22bb332867b48fbe40489f77a3d65814e4ac67e88044fe01aa6a944fc98016
Type coverMimetype application/pdf
fulltext(777 kB)1102 downloads
File information
File name FULLTEXT01.pdfFile size 777 kBChecksum MD5
91d507b4e0790b44d58f8f05f2afaa14f9be5bfb7b8ad3a160c30d1d1c381ca4a9286687
Type fulltextMimetype application/pdf

Authority records BETA

Bjarnegård, Niclas

Search in DiVA

By author/editor
Bjarnegård, Niclas
By organisation
Department of Medicine and Health SciencesFaculty of Health Sciences
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 1102 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 1793 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf