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Surface Immobilized Bisphosphonate Improves Stainless-Steel Screw Fixation in Rats
Linköping University, Department of Physics, Chemistry and Biology, Applied Physics . Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2004 (English)In: Biomaterials, ISSN 0142-9612, Vol. 25, no 11, 2133-2138 p.Article in journal (Refereed) Published
Abstract [en]

An increase in the mechanical fixation in bone of metallic biomaterials is considered advantageous in joint replacement and fracture surgery. Different approaches to improve fixation may be e.g. surface roughening, Ca-mineral coating or surface immobilization of growth factors or drugs. In the present work, bisphosphonate, a class of drugs that inhibit bone resorption, was immobilized onto stainless-steel screws.

The screws were first roughened and coated with immobilized and cross-linked fibrinogen. Subsequently, an N-bisphosphonate, pamidronate, was immobilized onto fibrinogen, and another N-bisphosphonate, ibandronate, adsorbed on top of this. The so coated screws were inserted into the tibiae of eight male Sprague-Dawley rats. Another eight rats received screws prepared in the same way, but without the bisphosphonate coating. Pullout strength tests were performed after 2 weeks of implantation.

The results showed a 28% (p=0.0009) higher pullout force and 90% increased pullout energy for the bisphosphonate coated screws, and support the idea that surface immobilized bisphosphonates can be used to improve biomaterials fixation in bone.

Place, publisher, year, edition, pages
2004. Vol. 25, no 11, 2133-2138 p.
Keyword [en]
Bisphosphonate, Immobilize, Bone, Pullout, Implant, Biomaterial
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-13040DOI: 10.1016/j.biomaterials.2003.08.049OAI: oai:DiVA.org:liu-13040DiVA: diva2:17707
Available from: 2008-03-14 Created: 2008-03-14 Last updated: 2009-08-21
In thesis
1. Following the mevalonate pathway to bone heal alley
Open this publication in new window or tab >>Following the mevalonate pathway to bone heal alley
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair.

Using two different rodent models of fracture repair, a commonly used cholesterol lowering drug (statin) and two drugs used to treat osteoporosis (bisphosphonate) were applied both systemically as well as locally in order to enhance fracture repair.

Papers I and II investigate the potential of simvastatin to improve the healing of femoral fractures in mice. Papers III and IV explore the use of two bisphosphonates to improve early fixation of stainless steel screws into rat bone.

The statin simvastatin lead to an increased strength of the healing cellus. The application of bisphosphonates increased early screw fixation.

It seems clear that both drugs have uses in orthopaedic applications. One interesting avenue of further research would be to combine the two classes of drugs and see if we can get the benefits while at the same time diminishing the drawbacks.

Place, publisher, year, edition, pages
Acta Orthopaedica, Volume 78, No. 328, 2007
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1033
Keyword
Bone screws, coated materials, biocompatible, chemistry, diphosphonates, pharmacology, Equipment failure analysis methods, Femoral fractures, drug therapy, fracture fixation, instrumentation, Fracture fixation, fracture healing, drug effects, simvastatin, tibial fractures, physiopathologyial fractures, surgery
National Category
Medicinal Chemistry Other Veterinary Science
Identifiers
urn:nbn:se:liu:diva-11282 (URN)978-91-85895-30-4 (ISBN)
Public defence
2007-12-12, Linden, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Available from: 2008-03-14 Created: 2008-03-14 Last updated: 2018-01-13

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Tengvall, PenttiSkoglund, BjörnAskendal, AgnetaAspenberg, Per

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Applied Physics The Institute of TechnologyOrthopaedics and Sports Medicine Faculty of Health SciencesDepartment of Orthopaedics LinköpingDepartment of Physics, Chemistry and Biology
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