Following the mevalonate pathway to bone heal alley
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair.
Using two different rodent models of fracture repair, a commonly used cholesterol lowering drug (statin) and two drugs used to treat osteoporosis (bisphosphonate) were applied both systemically as well as locally in order to enhance fracture repair.
Papers I and II investigate the potential of simvastatin to improve the healing of femoral fractures in mice. Papers III and IV explore the use of two bisphosphonates to improve early fixation of stainless steel screws into rat bone.
The statin simvastatin lead to an increased strength of the healing cellus. The application of bisphosphonates increased early screw fixation.
It seems clear that both drugs have uses in orthopaedic applications. One interesting avenue of further research would be to combine the two classes of drugs and see if we can get the benefits while at the same time diminishing the drawbacks.
Place, publisher, year, edition, pages
Acta Orthopaedica, Volume 78, No. 328 , 2007.
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1033
Bone screws, coated materials, biocompatible, chemistry, diphosphonates, pharmacology, Equipment failure analysis methods, Femoral fractures, drug therapy, fracture fixation, instrumentation, Fracture fixation, fracture healing, drug effects, simvastatin, tibial fractures, physiopathologyial fractures, surgery
Medicinal Chemistry Other Veterinary Science
IdentifiersURN: urn:nbn:se:liu:diva-11282ISBN: 978-91-85895-30-4OAI: oai:DiVA.org:liu-11282DiVA: diva2:17708
2007-12-12, Linden, Campus US, Linköpings universitet, Linköping, 13:00 (English)
List of papers