liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
History and signs of rheumatic disease in patients with significant heart valve disease
Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Clinical Physiology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences.
Show others and affiliations
2008 (English)Article in journal (Refereed) Submitted
Place, publisher, year, edition, pages
2008.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-13049OAI: oai:DiVA.org:liu-13049DiVA: diva2:17736
Available from: 2008-03-18 Created: 2008-03-18
In thesis
1. Signs of inflammation in different types of heart valve disease: The VOCIN study
Open this publication in new window or tab >>Signs of inflammation in different types of heart valve disease: The VOCIN study
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Heart valve dysfunction is a relatively common condition in the population, whereas significant heart valve disease is more unusual. The cause of different types of heart valve disease depends on which valve is concerned. Rheumatic heart valve disease, has for a long time been considered to constitute a post-inflammatory condition. During the 1990s it was also shown that the so-called non-rheumatic or degenerative tricuspid aortic stenosis, comprised signs of inflammation.

In this study, 118 patients (the VOCIN study group) referred to the University Hospital for preoperative investigation due to significant heart valve disease, were examined regarding signs of inflammation.

Twenty-nine aortic valves from patients with significant aortic stenosis were divided into tricuspid and bicuspid aortic valves. The bicuspid aortic stenotic valves revealed signs of inflammation to a similar extent as the tricuspid valves. However, the tricuspid and bicuspid valves differed regarding distribution of calcification. In contrast, inflammation was not a predominant feature in 15 aortic and mitral valves from patients with significant heart valve regurgitation.

Gross valvular pathology consistent with rheumatic aortic stenosis was found in 10 patients. These valves revealed a somewhat lower degree of inflammatory cell infiltration, but on the whole, there were no substantial differences when compared to non-rheumatic aortic stenotic valves. They did, however, reveal a similar distribution of calcification as the bicuspid, non-rheumatic aortic valves.

The VOCIN study group was compared to an age- and gender matched control group with regard to history and signs of rheumatic disease. There was not any increased prevalence of clinical manifestations of non-cardiac inflammatory disease in patients with significant heart valve disease, when compared to healthy control subjects. However, patients with heart valve disease had significantly increased serum levels of inflammatory markers compared to controls. The increase in inflammatory markers remained significant even in the subgroup of non-rheumatic aortic stenosis devoid of coronary artery disease. These results indicate that a systemic inflammatory component is associated with stenotic, non-rheumatic heart valve disease.

The similarities between different forms of calcific aortic valve disease indicate a similar pathogenesis. The question is raised whether aortic stenosis is one disease, mainly caused by a general and non-specific response to dynamic tissue stress due to an underlying malformation of the valve.

Place, publisher, year, edition, pages
Institutionen för medicin och hälsa, 2008. 55 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1052
Keyword
Heart valve dysfunction, heart valve disease, VOCIN study group, aortic valves, Gross valvular pathology
National Category
Dentistry
Identifiers
urn:nbn:se:liu:diva-11330 (URN)978-91-7393-949-2 (ISBN)
Public defence
2008-04-18, Berzeliussalen, Campus US, Linköpings universitet, Linköping, 09:00 (English)
Opponent
Supervisors
Available from: 2008-03-18 Created: 2008-03-18 Last updated: 2009-08-22

Open Access in DiVA

No full text

Other links

Link to Ph.D. thesis

Authority records BETA

Wallby, LarsJanerot Sjöberg, BirgittaJonasson, LenaBroqvist, Mats

Search in DiVA

By author/editor
Wallby, LarsJanerot Sjöberg, BirgittaJonasson, LenaBroqvist, Mats
By organisation
Cardiology Faculty of Health SciencesClinical Physiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 92 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf