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Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Lulea Univ Technol, Sweden.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0003-1755-5654
Brno Univ Technol, Czech Republic.
2023 (English)In: ChemBioChem, ISSN 1439-4227, E-ISSN 1439-7633, Vol. 24, no 17, article id e202300353Article in journal (Refereed) Published
Abstract [en]

Reactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2023. Vol. 24, no 17, article id e202300353
Keywords [en]
bioelectronics; Fenton reaction; oxygen reduction reaction; reactive oxygen species
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-196629DOI: 10.1002/cbic.202300353ISI: 001037281000001PubMedID: 37184620OAI: oai:DiVA.org:liu-196629DiVA, id: diva2:1788640
Note

Funding Agencies|European Research Council (ERC) under the European Union [949191]; Grant Agency of the Czech Republic [23-07432S]; Brno City Municipality; Knut and Alice Wallenberg foundation; LTU labbfond

Available from: 2023-08-16 Created: 2023-08-16 Last updated: 2024-07-04Bibliographically approved

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Miglbauer, EvaGryszel, Maciej

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