In vivo determination of local skin optical properties and photon path length by use of spatially resolved diffuse reflectance with applications in laser Doppler flowmetry
2003 (English)In: Applied Optics, ISSN 0003-6935, Vol. 42, no 7-8, 124-134 p.Article in journal (Refereed) Published
Methods for local photon pathlength and optical properties estimation, based on measured and simulated diffuse reflectance within 2mm from the light source, are proposed and evaluated in vivo on Caucasian human skin. The accuracy of the methods was good (2-7%) for pathlength and reduced scattering but poor for absorption estimation. Reduced scattering and absorption were systematically lower in the fingertip than in the forearm skin (633 nm). A maximum intra-site and inter-individual variation of ~35% in the average photon pathlength was found. The methodology was applied in laser Doppler flowmetry (LDF), where pathlength normalization of the estimated perfusion removed the optical property dependency.
Place, publisher, year, edition, pages
Institutionen för medicinsk teknik , 2003. Vol. 42, no 7-8, 124-134 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-11658DOI: 10.1364/AO.42.000124OAI: oai:DiVA.org:liu-11658DiVA: diva2:18068
Larsson, M., Nilsson, H. & Strömberg, T., In vivo determination of local skin optical properties and photon path length by use of spatially resolved diffuse reflectance with applications in laser Doppler flowmetry, 2003, Applied Optics, (42), 7-8, 124-134. http://dx.doi.org/10.1364/AO.42.000124. This paper was published in Applied Optics and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://ao.osa.org/abstract.cfm?id=70860. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law. Copyright OSA., http://www.osa.org/2008-04-242008-04-242016-08-31