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Changing epidemiology, global trends and implications for outcomes of NAFLD
Chinese Univ Hong Kong, Peoples R China.
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken.ORCID iD: 0000-0002-5590-8601
Chinese Univ Hong Kong, Peoples R China; Prince Wales Hosp, Peoples R China.
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden.
2023 (English)In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 79, no 3, p. 842-852Article, review/survey (Refereed) Published
Abstract [en]

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease globally and is currently estimated to affect 38% of the global population. Only a minority of patients with NAFLD will progress to cirrhosis or hepatocellular carcinoma, but from this vast population the total number of patients who are at risk of such severe outcomes is increasing. Worryingly, individuals are increasingly being affected by NAFLD at an earlier age, meaning there is more time for them to develop severe complications. With considerable changes in dietary composition and urbanisation, alongside the growth in obesity and type 2 diabetes in the global population, in particular in developing countries, the global proportion of persons affected by NAFLD is projected to increase further. Yet, there are large geographical discrepancies in the prevalence rates of NAFLD and its inflammatory component non-alcoholic steatohepatitis (NASH). Such differences are partly related to differing socio-economic milieus, but also to genetic predisposition. In this narrative review, we discuss recent changes in the epidemiology of NAFLD and NASH from regional and global perspectives, as well as in special populations. We also discuss the potential consequences of these changes on hepatic and extrahepatic events. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Place, publisher, year, edition, pages
ELSEVIER , 2023. Vol. 79, no 3, p. 842-852
Keywords [en]
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Obesity; Metabolic syndrome; diabetes; NASH; Epidemic.
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-198686DOI: 10.1016/j.jhep.2023.04.036ISI: 001076337600001PubMedID: 37169151OAI: oai:DiVA.org:liu-198686DiVA, id: diva2:1806829
Note

Funding Agencies|Chinese University of Hong Kong [2021.027]; Swedish Research Council [2021-01293]

Available from: 2023-10-24 Created: 2023-10-24 Last updated: 2024-04-08

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