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Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context
Univ Skovde, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-4506-1881
Univ Skovde, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-1107-5644
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2023 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 12, article id e81197Article in journal (Refereed) Published
Abstract [en]

Both oxytocin (OT) and touch are key mediators of social attachment. In rodents, tactile stimulation elicits the endogenous release of OT, potentially facilitating attachment and other forms of prosocial behavior, yet the relationship between endogenous OT and neural modulation remains unexplored in humans. Using a serial sampling of plasma hormone levels during functional neuroimaging across two successive social interactions, we show that contextual circumstances of social touch influence not only current hormonal and brain responses but also later responses. Namely, touch from a male to his female romantic partner enhanced her subsequent OT release for touch from an unfamiliar stranger, yet females OT responses to partner touch were dampened following stranger touch. Hypothalamus and dorsal raphe activation reflected plasma OT changes during the initial social interaction. In the subsequent interaction, precuneus and parietal-temporal cortex pathways tracked time- and context-dependent variables in an OT-dependent manner. This OT-dependent cortical modulation included a region of the medial prefrontal cortex that also covaried with plasma cortisol, suggesting an influence on stress responses. These findings demonstrate that modulation between hormones and the brain during human social interactions can flexibly adapt to features of social context over time.

Place, publisher, year, edition, pages
eLIFE SCIENCES PUBL LTD , 2023. Vol. 12, article id e81197
Keywords [en]
oxytocin; touch; fMRI
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-198987DOI: 10.7554/eLife.81197ISI: 001075012600001PubMedID: 37157840OAI: oai:DiVA.org:liu-198987DiVA, id: diva2:1810260
Note

Funding Agencies|Vetenskapsradet [FYF-2013-687]

Available from: 2023-11-07 Created: 2023-11-07 Last updated: 2024-05-06

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Novembre, GiovanniKämpe, RobinPaul, ElisabethMorrison, India
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