Absolute flow velocity components in laser Doppler flowmetry
2006 (English)In: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, Vol. 6094, 60940A- p.Article in journal (Refereed) Published
A method to separate a Doppler power spectrum into a number of flow velocity components, measured in absolute units (mm/s), is presented. A Monte Carlo software was developed to track each individual Doppler shift, to determine the probability, p(n), for a photon to undergo n Doppler shifts. Given this shift distribution, a mathematical relationship was developed and used to calculate a Doppler power spectrum originating from a certain combination of velocity components. The non linear Levenberg-Marquardt optimization method could thus be used to fit the calculated and measured Doppler power spectra, giving the true set of velocity components in the measured sample. The method was evaluated using a multi tube flow phantom perfused with either polystyrene microspheres or undiluted/diluted human blood (hct = 0.45). It estimated the velocity components in the flow phantom well, during both low and high concentrations of moving scatterers (microspheres or blood). Thus, further development of the method could prove to be a valuable clinical tool to differentiate capillary blood flow.
Place, publisher, year, edition, pages
IEEE , 2006. Vol. 6094, 60940A- p.
Laser Doppler flowmetry, LDF, Monte Carlo simulations, flow phantom, blood perfusion, scattering phase
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-11703DOI: 10.1117/12.659206OAI: oai:DiVA.org:liu-11703DiVA: diva2:18125
Ingemar Fredriksson, Marcus Larsson and Tomas Strömberg, Absolute flow velocity components in laser Doppler flowmetry, 2006, Proceedings of SPIE -- Volume 6094 Optical Diagnostics and Sensing VI. http://dx.doi.org/10.1117/12.659206. Copyright 2006 Society of Photo-Optical Instrumentation Engineers. This paper was published in Proceedings of SPIE -- Volume 6094 Optical Diagnostics and Sensing VI and is made available as an electronic reprint with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.2008-04-292008-04-292016-08-31Bibliographically approved