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Associations of health-related quality of life with major adverse cardiovascular and cerebrovascular events for individuals with ischaemic heart disease: systematic review, meta-analysis and evidence mapping
Almazov Natl Med Res Ctr, Russia.
Univ Leeds, England.
Univ Vermont, VT USA.
Univ Leeds, England.
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2023 (English)In: Open heart, E-ISSN 2053-3624, Vol. 10, no 2, article id e002452Article, review/survey (Refereed) Published
Abstract [en]

ObjectiveTo investigate the association between health-related quality of life (HRQoL) and major adverse cardiovascular and cerebrovascular events (MACCE) in individuals with ischaemic heart disease (IHD).MethodsMedline(R), Embase, APA PsycINFO and CINAHL (EBSCO) from inception to 3 April 2023 were searched. Studies reporting association of HRQoL, using a generic or cardiac-specific tool, with MACCE or components of MACCE for individuals with IHD were eligible for inclusion. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale to assess the quality of the studies. Descriptive synthesis, evidence mapping and random-effects meta-analysis were performed stratified by HRQoL measures and effect estimates. Between-study heterogeneity was assessed using the Higgins I2 statistic.ResultsFifty-one articles were included with a total of 134 740 participants from 53 countries. Meta-analysis of 23 studies found that the risk of MACCE increased with lower baseline HeartQoL score (HR 1.49, 95% CI 1.16 to 1.93) and Short Form Survey (SF-12) physical component score (PCS) (HR 1.39, 95% CI 1.28 to 1.51). Risk of all-cause mortality increased with a lower HeartQoL (HR 1.64, 95% CI 1.34 to 2.01), EuroQol 5-dimension (HR 1.17, 95% CI 1.12 to 1.22), SF-36 PCS (HR 1.29, 95% CI 1.19 to 1.41), SF-36 mental component score (HR 1.18, 95% CI 1.08 to 1.30).ConclusionsThis study found an inverse association between baseline values or change in HRQoL and MACCE or components of MACCE in individuals with IHD, albeit with between-study heterogeneity. Standardisation and routine assessment of HRQoL in clinical practice may help risk stratify individuals with IHD for tailored interventions.PROSPERO registration numberCRD42021234638.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2023. Vol. 10, no 2, article id e002452
Keywords [en]
health-related quality of life; cardiovascular outcomes; mortality; systematic review; meta-analysis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-199343DOI: 10.1136/openhrt-2023-002452ISI: 001094950500003PubMedID: 37890894OAI: oai:DiVA.org:liu-199343DiVA, id: diva2:1815344
Note

Funding Agencies|We thank Deirdre Andre for assistance with electronic search strategy.

Available from: 2023-11-28 Created: 2023-11-28 Last updated: 2024-09-12

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