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Polyethylene glycol-cover ultra-small Gd2O3 nanoparticles for positive contras at 1.5 T magnetic resonance clinical scanning
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Physical Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.
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2007 (English)In: Nanotechnology, ISSN 0957-4484, Vol. 18, no 39, 395501- p.Article in journal (Refereed) Published
Abstract [en]

The size distribution and magnetic properties of ultra-small gadolinium oxide crystals (US-Gd2O3) were studied, and the impact of polyethylene glycol capping on the relaxivity constants (r1, r2) and signal intensity with this contrast agent was investigated. Size distribution and magnetic properties of US-Gd2O3 nanocrystals were measured with a TEM and PPMS magnetometer. For relaxation studies, diethylene glycol (DEG)-capped US-Gd2O3 nanocrystals were reacted with PEG-silane (MW 5000). Suspensions were adequately dialyzed in water to eliminate traces of Gd3+ and surfactants. The particle hydrodynamic radius was measured with dynamic light scattering (DLS) and the proton relaxation times were measured with a 1.5 T MRI scanner. Parallel studies were performed with DEG–Gd2O3 and PEG-silane–SPGO (Gd2O3,< 40 nm diameter). The small and narrow size distribution of US-Gd2O3 was confirmed with TEM (~3 nm) and DLS. PEG-silane–US-Gd2O3 relaxation parameters were twice as high as for Gd–DTPA and the r2/r1 ratio was 1.4. PEG-silane–SPGO gave low r1 relaxivities and high r2/r1 ratios, less compatible with positive contrast agent requirements. Higher r1 were obtained with PEG-silane in comparison to DEG–Gd2O3. Treatment of DEG–US-Gd2O3 with PEG-silane provides enhanced relaxivity while preventing aggregation of the oxide cores. This study confirms that PEG-covered Gd2O3 nanoparticles can be used for positively contrasted MR applications requiring stability, biocompatible coatings and nanocrystal functionalization.

Place, publisher, year, edition, pages
2007. Vol. 18, no 39, 395501- p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-13297DOI: 10.1088/0957-4484/18/39/395501ISI: 000249283300006OAI: oai:DiVA.org:liu-13297DiVA: diva2:18246
Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2015-12-17
In thesis
1. Colloidal synthesis of metal oxide nanocrystals and thin films
Open this publication in new window or tab >>Colloidal synthesis of metal oxide nanocrystals and thin films
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A main driving force behind the recent years’ immense interest in nanoscience and nanotechnology is the possibility of achieving new material properties and functionalities within, e.g., material physics, biomedicine, sensor technology, chemical catalysis, energy storing systems, and so on. New (theoretical) possibilities represent, in turn, a challenging task for chemists and physicists. An important feature of the present nanoscience surge is its strongly interdisciplinary character, which is reflected in the present work.

In this thesis, nanocrystals and thin films of magnetic and ferroelectric metal oxides, e.g. RE2O3 (RE = Y, Gd, Dy), GdFeO3, Gd3Fe5O12, Na0.5K0.5NbO3, have been prepared by colloidal and sol-gel methods. The sizes of the nanocrystals were in the range 3-15 nm and different carboxylic acids, e.g. oleic or citric acid, were chemisorbed onto the surface of the nanoparticles. From FT-IR measurements it is concluded that the bonding to the surface takes place via the carboxylate group in a bidentate or bridging fashion, with some preference for the latter coordination mode. The magnetic properties of nanocrystalline Gd2O3 and GdFeO3 were measured, both with respect to magnetic resonance relaxivity and magnetic susceptibility. Both types of materials exhibit promising relaxivity properties, and may have the potential for use as positive contrast enhancing agents in magnetic resonance imaging (MRI). The nanocrystalline samples were also characterised by transmission electron microscopy (TEM), x-ray photoelectron spectroscopy (XPS), and quantum chemical calculations.

Thin films of Na0.5K0.5NbO3, GdFeO3 and Gd3Fe5O12 were prepared by sol-gel methods and characterized by x-ray powder diffraction (XRPD) and scanning electron microscopy (SEM). Under appropriate synthesis conditions, rather pure phase materials could be obtained with grain sizes ranging from 50 to 300 nm. Magnetic measurements in the temperature range 2-350 K indicated that the magnetization of the perovskite phase GdFeO3 can be described as the sum of two contributing terms. One term (mainly) due to the spontaneous magnetic ordering of the iron containing sublattice, and the other a susceptibility term, attributable to the paramagnetic gadolinium sublattice. The two terms yield the relationship M(T)=M0(T)+χ(T)*H for the magnetization. The garnet phase Gd3Fe5O12 is ferrimagnetic and showed a compensation temperature Tcomp ≈ 295 K.

Place, publisher, year, edition, pages
Institutionen för fysik, kemi och biologi, 2008
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1182
Keyword
nanoparticles, synthesis, contrast agents, functionalization, thin films
National Category
Chemical Sciences
Identifiers
urn:nbn:se:liu:diva-11831 (URN)978-91-7393-899-0 (ISBN)
Public defence
2008-06-10, Planck, Fysikhuset, Campus Valla, Linköpings Universitet, Linköping, 10:15 (English)
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Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2009-05-15

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Fortin, Marc-AndréPetoral Jr, Rodrigo M.Söderlind, FredrikKlasson, AnnaEngström, MariaKäll, Per-OlovUvdal, Kajsa

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Fortin, Marc-AndréPetoral Jr, Rodrigo M.Söderlind, FredrikKlasson, AnnaEngström, MariaKäll, Per-OlovUvdal, Kajsa
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Molecular Surface Physics and Nano ScienceFaculty of Science & EngineeringPhysical ChemistryCenter for Medical Image Science and Visualization (CMIV)RadiologyFaculty of Health SciencesThe Institute of Technology
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