Functional Dyspepsia Affects Woman More Than Men in Daily Life: A Case-Control Study in Primary Care
2008 (English)In: Gender Medicine, Vol. 5, no 1, 62-73 p.Article in journal (Refereed) Published
Background: Little is known about possible gender differences among patients with functional dyspepsia (FD). Few studies have measured health-related quality of life (HRQoL) in patients with FD using a population-based control group as a reference.
Objective: This study aimed to determine the degree of HRQoL impairment among patients with FD, assess the self-reported health impact resulting from the disease, and analyze any gender differences.
Methods: A questionnaire that included the HRQoL Short Form 36 (SF-36) Health Survey, the HAD Scale and other measurements was mailed to FD patients identified from medical records and control group randomly selected from the general population in the same geographical area. Responses to the SF-36 were transferred to a standard scale ranging from 0 (the worst possible score) to 100 (the best possible score).
Results: A total of 176 patients with FD and 688 controls responded to the questionnaire. Responders were assigned to 2 gender-specific subgroups of 88 patients with FD and 344 randomly matched controls, all aged 18 to 65 years. HRQoL of the patients with FD was impaired in all SF-36 dimensions except one—role limitations caused by emotional problems compared with the controls. Female patients with FD had a significantly lower SF-36 score in the physical functioning dimension than did male patients (82.4 vs 90.5, respectively; P < 0.01). Both groups of patients with FD had impaired HRQoL compared with their respective control group in the dimensions of bodily pain (women: 69.3 vs 80.6; P < 0.001; and men: 75.8 vs 84.8; P < 0.001) and general health (women: 62.0 vs 75.6; P < 0.001; and men: 70.6 vs 78.6; P < 0.001). Additionally, women with FD had significant impairment compared with their respective control group in the dimensions of physical function (82.4 vs 89.3; P < 0.01) and physical role function (72.1 vs 85.9; P < 0.001). Depression was significantly more common among male patients with FD than among male controls (6.8% vs 2.0%, respectively; P < 0.05). More gastrointestinal comorbidity was reported among patients of both sexes compared with controls.
Conclusions: This population-based case-control study reported HRQoL impairment overall among patients with FD. This impairment was more apparent among female patients compared with female controls. Females with FD tend to be more negatively affected in their daily life compared with their male counterparts. These gender differences should be investigated further in future studies.
Place, publisher, year, edition, pages
Institutionen för medicin och hälsa , 2008. Vol. 5, no 1, 62-73 p.
functional dyspepsia, HRQoL, gender, case-control study
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-11864DOI: 10.1016/S1550-8579(08)80009-5OAI: oai:DiVA.org:liu-11864DiVA: diva2:18265
Original publication: Kerstin Welén, Åshild Faresjö and Tomas Faresjö, Functional Dyspepsia Affects Woman More Than Men in Daily Life: A Case-Control Study in Primary Care, Gender Medicine, (5), 1, 62-73. http://dx.doi.org/10.1016/S1550-8579(08)80009-5. Copyright: Elsevier, http://www.elsevier.com/ Postprint available free at: Linköping University E-Press: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118642008-05-212008-05-212014-01-20