Peak oxygen uptake in combination with ventilatory efficiency improve risk stratification in major abdominal surgeryShow others and affiliations
2024 (English)In: Physiological Reports, E-ISSN 2051-817X, Vol. 12, no 1, article id e15904Article in journal (Refereed) Published
Abstract [en]
This pilot study aimed to evaluate if peak VO2 and ventilatory efficiency in combination would improve preoperative risk stratification beyond only relying on peak VO2. This was a single-center retrospective cohort study including all patients who underwent cardiopulmonary exercise testing (CPET) as part of preoperative risk evaluation before major upper abdominal surgery during years 2008-2021. The primary outcome was any major cardiopulmonary complication during hospitalization. Forty-nine patients had a preoperative CPET before decision to pursue to surgery (cancer in esophagus [n = 18], stomach [6], pancreas [16], or liver [9]). Twenty-five were selected for operation. Patients who suffered any major cardiopulmonary complication had lower ventilatory efficiency (i.e., higher VE/VCO2 slope, 37.3 vs. 29.7, p = 0.031) compared to those without complications. In patients with a low aerobic capacity (i.e., peak VO2 < 20 mL/kg/min) and a VE/VCO2 slope >= 39, 80% developed a major cardiopulmonary complication. In this pilot study of patients with preoperative CPET before major upper abdominal surgery, patients who experienced a major cardiopulmonary complication had significantly lower ventilatory efficiency compared to those who did not. A low aerobic capacity in combination with low ventilatory efficiency was associated with a very high risk (80%) of having a major cardiopulmonary complication.
Place, publisher, year, edition, pages
WILEY , 2024. Vol. 12, no 1, article id e15904
Keywords [en]
abdominal surgery; cardiopulmonary exercise testing; exercise capacity; functional capacity; ventilatory efficiency
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-200246DOI: 10.14814/phy2.15904ISI: 001134587000001PubMedID: 38163673OAI: oai:DiVA.org:liu-200246DiVA, id: diva2:1829433
Note
Funding Agencies|ALF Grants
2024-01-192024-01-192024-01-19