The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled TrialShow others and affiliations
2023 (English)In: Archives of Rehabilitation Research and Clinical Translation, E-ISSN 2590-1095, Vol. 5, no 4, article id 100297Article in journal (Refereed) Published
Abstract [en]
Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6).Design: Randomized controlled trial.Setting: Community-dwelling women in Stockholm.Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113).Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months. Main Outcome Measure(s): QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms.Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women.Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed.(c) 2023 The Authors. Published by Elsevier Inc. on behalf of American Congress of Rehabilitation Medicine.
Place, publisher, year, edition, pages
ELSEVIER , 2023. Vol. 5, no 4, article id 100297
Keywords [en]
Biomarkers; Osteoporosis; Pain; Quality of life; Rehabilitation; Women
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:liu:diva-200276DOI: 10.1016/j.arrct.2023.100297ISI: 001135699000001PubMedID: 38163036OAI: oai:DiVA.org:liu-200276DiVA, id: diva2:1829963
2024-01-222024-01-222024-11-25