Genome and proteomic analysis of risk factors for fatal outcome in children with severe community-acquired pneumonia caused by human adenovirus 7Show others and affiliations
2023 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 95, no 11, article id e29182Article in journal (Refereed) Published
Abstract [en]
Introduction: Human adenovirus 7 (HAdV-7) is an important viral pathogen of severe pneumonia in children and a serious threat to health. Methods: A cohort of 45 pediatric patients diagnosed with HAdV-7-associated severe pneumonia and admitted to the Pediatric Intensive Care Unit at the Children's Hospital of Chongqing Medical University from May 2018 to January 2020 were included. Risk factors of death were analyzed by the Cox proportional risk mode with Clinical data, serum, and nasopharyngeal aspirate adenovirus load, Genome analysis, Olink proteomics, and cytokine profile between dead and surviving patients were also analyzed. Results: A total of 45 children with a median age of 12.0 months (interquartile range [IQR]: 6.5, 22.0) were included (female 14), including 14 (31.1%) who died. High serum viral load was an independent risk factor for mortality (hazard ratio [HR] = 2.16, 95% confidence interval [CI], 1.04-4.49, p = 0.039). BTB and CNC homology 1 (BACH1), interleukin-5 (IL-5), and IL-9 levels were significantly correlated with serum viral load (p = 0.0400, 0.0499, and 0.0290; r = 0.4663, 0.3339, and -0.3700, respectively), with significant differences between the dead and survival groups (p = 0.021, 0.001, and 0.021). Conclusions: Severe cytokine storm-associated high serum viral load after HAdV-7 infection may be the main mechanism responsible for poor prognosis in children.
Place, publisher, year, edition, pages
WILEY , 2023. Vol. 95, no 11, article id e29182
Keywords [en]
human adenovirus 7; mortality; risk factors; severe community-acquired pneumonia
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-201036DOI: 10.1002/jmv.29182ISI: 001124416600002PubMedID: 37909805OAI: oai:DiVA.org:liu-201036DiVA, id: diva2:1840302
Note
Funding Agencies|General Project of National Natural Science Foundation of China [32071123]; Chongqing Science and Health Joint project [2020FYYX148]; Ministry of Education Key Laboratory of Child Development and Disorders [YBRP-2021XX]; National Natural Science Foundation of China [32170139]; CQMU Program for Youth Innovation in Future Medicine [W0178]; Chongqing high-end medicine for young and middle-aged people Talent Program [CQYC202203091217]
2024-02-232024-02-232024-02-23