IL-8 and tumor necrosis factor alpha in heart valves from patients with infective endocarditis
2002 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548 (print), 1651-1980 (online), Vol. 34, no 10, 759-762 p.Article in journal (Refereed) Published
The embedding of bacteria in the vegetation of infective endocarditis impedes the penetration of phagocytic cells. IL-8 has a stimulating effect on the immune system, particularly with respect to chemotaxis and activation of granulocytes. Tumor necrosis factor alpha (TNF-) is 1 of the major proinflammatory cytokines. IL-8 and TNF- were visualized by means of immunohistochemistry in paraffin-embedded heart valve biopsies from 6 patients with infective endocarditis who required cardiac surgery during the active phase of the infection. In 5/6 patients there were signs of inflammation, and in these patients IL-8- and TNF- -containing cells were visualized in the heart valve stromas or vegetations. The largest numbers of IL-8-containing cells, and the greatest amount of inflammation, were seen in patients with short preoperative treatment courses. No such relationships were seen with respect to TNF- -containing cells. These observations may suggest that the occurrence of IL-8-containing cells in infected heart valves could be used as a marker of disease activity.
Place, publisher, year, edition, pages
2002. Vol. 34, no 10, 759-762 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-13332DOI: 10.1080/00365540210147912OAI: oai:DiVA.org:liu-13332DiVA: diva2:18505