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Expresson of PTEN and SHP1, Ivestigated from Tissue Microarrays in Pediatric Acute Lymphoblastic, Leukemia
Karolinska University Hospital.
Malmö University Hospital.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
Karolinska Institute.
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2009 (English)In: Pediatric Hematology & Oncology, ISSN 0888-0018, Vol. 26, no 1, 48-56 p.Article in journal (Refereed) Published
Abstract [en]

PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.

Place, publisher, year, edition, pages
2009. Vol. 26, no 1, 48-56 p.
Keyword [en]
pediatric leukemia, PTEN, SHP1, tissue microarray
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16959DOI: 10.1080/08880010802625530OAI: diva2:200846
Available from: 2009-02-28 Created: 2009-02-27 Last updated: 2009-09-22

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Gustafsson, Bertil
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Department of Clinical and Experimental MedicineFaculty of Health SciencesDepartment of Clinical Pathology and Clinical Genetics
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