Expresson of PTEN and SHP1, Ivestigated from Tissue Microarrays in Pediatric Acute Lymphoblastic, Leukemia
2009 (English)In: Pediatric Hematology & Oncology, ISSN 0888-0018, Vol. 26, no 1, 48-56 p.Article in journal (Refereed) Published
PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
Place, publisher, year, edition, pages
2009. Vol. 26, no 1, 48-56 p.
pediatric leukemia, PTEN, SHP1, tissue microarray
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-16959DOI: 10.1080/08880010802625530OAI: oai:DiVA.org:liu-16959DiVA: diva2:200846