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Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients
Umeå University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
Lund University Hospital.
Malmö University Hospital.
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2009 (English)In: Journal of Hepatology, ISSN 0168-8278, Vol. 50, no 2, 388-393 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients.

Methods: Four hundred and seventy-three patients with AIH were matched to the Swedish national cancer register as well as to the death cause register.

Results: We found an overall higher risk of malignancies in the cohort of A I H patients from the date of diagnosis with a SIR of 1.51 (95% CI 1.10-2.03). SIR in the subpopulation of well defined catchment areas and complete case finding was 23.28 (95% CI 7.5-54.34) for HCC. Lymphomas were found a SIR of 13.09 (95% CI 4.22-30.56).

Conclusions: There was an overall increased risk of malignancies in a cohort of AIH patients, which manly was caused by hepatobiliary cancers. However, the true risk of HCC in an AIH cirrhotic cohort has yet to be investigated. A significantly higher risk of lymphomas was also found, but no clear cut association to the use of immune modulators.

Place, publisher, year, edition, pages
2009. Vol. 50, no 2, 388-393 p.
Keyword [en]
Autoimmune hepatitis, Hepatocellular carcinoma, Lymphoma, Malignancies
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-16964DOI: 10.1016/j.jhep.2008.08.022OAI: diva2:200851
Available from: 2009-02-28 Created: 2009-02-27 Last updated: 2009-08-21

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Almer, Sven
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Gastroenterology and Hepatology Faculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHL
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