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Leucocyte esterase testing of first-voided urine and urethral and cervical smears to identify Mycoplasma genitalium-infected men and women.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences.
2007 (English)In: International Journal of STD and AIDS (London), ISSN 0956-4624, Vol. 18, no 12, 835-838 p.Article in journal (Refereed) Published
Abstract [en]

Leucocyte esterase (LE) in first-voided urine (FVU) and presence of leucocytes in urethral and cervical smears were evaluated to identify Mycoplasma genitalium infection in 416 men and 417 women attending Department of Genitourinary Medicine. M. genitalium was diagnosed in FVU specimens by realtime polymerase chain reaction. The prevalence of M. genitalium was 6.5% in women and 6.7% in men. In total, 88.5% (23/26) of M. genitalium-infected men were identified by a combination of urethral smear and the LE test. In women, the combination of urethral and/or cervical smears and/or a positive LE test identified 91.3% (21/23) of M. genitalium-infected patients. Organism load in FVU correlated significantly with presence of urethritis (> or =4 leucocytes per high-power field) in men. A combination of LE testing of urine and urethral and/or cervical smears can be used as screening tests to select patients for specific M. genitalium testing. By this strategy, about 10% of infected individuals will remain undetected.

Place, publisher, year, edition, pages
2007. Vol. 18, no 12, 835-838 p.
Keyword [en]
Mycoplasma genitalium, leucocyte esterase, real-time PCR
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-17127DOI: 10.1258/095646207782716983PubMedID: 18073017OAI: oai:DiVA.org:liu-17127DiVA: diva2:202103
Available from: 2009-03-06 Created: 2009-03-06 Last updated: 2009-08-19

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Högdahl, MarieKihlström, Erik

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Clinical Microbiology Faculty of Health SciencesDepartment of Clinical Microbiology
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