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Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL. (Landstinget i Östergötland)
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences.
2006 (English)In: FEMS Immunology and Medical Microbiology, ISSN 0928-8244, E-ISSN 1574-695X, Vol. 47, no 2, 207-216 p.Article in journal (Refereed) Published
Abstract [en]

Atherosclerosis and coronary heart disease are causing high morbidity and mortality worldwide. Different risk factors have been demonstrated, but the exact mechanisms behind these diseases are still not fully understood. Recent studies have suggested Chlamydia pneumoniae to be involved in the pathogenesis, and increased apoptotic indexes in atherosclerotic plaques have been documented. In this study, we show that C. pneumoniae induces apoptosis and necrosis in populations of human coronary artery endothelial cells. Apoptosis was determined by TUNEL and flow cytometry after staining of cells with annexin V and propidium iodide, and defined as TUNEL-reactive or annexin V-positive, propidium iodide-negative cells. The apoptosis was induced within 2 h postinfection and increased with inoculation dose. The general caspase inhibitor z-VAD-fmk did not affect apoptotic frequencies. By immunochemistry and immunoblot, we demonstrated activation and subcellular translocation of the proapoptotic protein Bax, and translocation of apoptosis-inducing factor from the cytosol to the nucleus. These results indicate that C. pneumoniae-induced apoptosis in human coronary artery endothelial cells is caspase-independent and regulated by Bax and apoptosis-inducing factor.

Place, publisher, year, edition, pages
2006. Vol. 47, no 2, 207-216 p.
Keyword [en]
Chlamydia pneumoniae, coronary cells, apoptosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-17128DOI: 10.1111/j.1574-695X.2006.00083.xPubMedID: 16831207OAI: oai:DiVA.org:liu-17128DiVA: diva2:202104
Note
The definitive version is available at www.blackwell-synergy.com:Johan Schöier, Marie Högdahl, Gustaf Söderlund and Erik Kihlström, Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor., 2006, FEMS Immunology and Medical Microbiology, (47), 2, 207-216.http://dx.doi.org/10.1111/j.1574-695X.2006.00083.xCopyright: Blackwell Publishing Ltd. http://www.blackwellpublishing.com/and Scandinavian Societies for Medical Microbiology and PathologyAvailable from: 2009-03-07 Created: 2009-03-06 Last updated: 2017-12-13Bibliographically approved

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Schöier, JohanHögdahl, MarieKihlström, Erik

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